Skip to main content
Journal cover image

Evaluation of tacrolimus abbreviated area-under-the-curve monitoring in renal transplant patients who are potentially at risk for adverse events.

Publication ,  Journal Article
Hon, YY; Chamberlain, CE; Kleiner, DE; Ring, MS; Hale, DA; Kirk, AD; Mannon, RB
Published in: Clin Transplant
2010

In a cohort of 32 renal transplant patients who are potentially at risk for adverse events, we compared tacrolimus (TAC) abbreviated AUC values calculated by a method developed in Asians (AUCw) with those derived for Caucasians (AUCa). The relationships between TAC trough (C0), abbreviated AUC, and biopsy results were also assessed. Forty-eight AUCs and 15 associated biopsies were evaluated. For AUCs obtained only from Caucasian patients, median AUCw value was lower than that of AUCa (104 vs. 115 ng×h/mL, n=29, p<0.0001). AUCs obtained from the two methods for all patients correlated with C0 (rs>0.72, n=48, p<0.0001). Median AUCw (72.9 vs. 174 ng×h/mL, p=0.043) and AUCa (81.0 vs. 203 ng×h/mL, p=0.043) were lower in patients experiencing biopsy-proven acute rejection (AR) than those with normal histology. C0 tended to be lower in biopsies showing AR>6 months post-transplant (5.80 vs. 11.0 ng/mL, p=0.110). Thus, lower abbreviated AUCs were obtained for Caucasians using a method developed in Asians. C0 correlated well with abbreviated AUCs. Lower C0 and AUC appeared to be associated with biopsy-proven AR>6 months post-transplant. Further prospective evaluation of TAC AUC and C0 monitoring in a larger cohort of patients is warranted.

Duke Scholars

Published In

Clin Transplant

DOI

EISSN

1399-0012

Publication Date

2010

Volume

24

Issue

4

Start / End Page

557 / 563

Location

Denmark

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • Time Factors
  • Tacrolimus
  • Survival Rate
  • Surgery
  • Middle Aged
  • Male
  • Kidney Transplantation
  • Immunosuppressive Agents
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hon, Y. Y., Chamberlain, C. E., Kleiner, D. E., Ring, M. S., Hale, D. A., Kirk, A. D., & Mannon, R. B. (2010). Evaluation of tacrolimus abbreviated area-under-the-curve monitoring in renal transplant patients who are potentially at risk for adverse events. Clin Transplant, 24(4), 557–563. https://doi.org/10.1111/j.1399-0012.2009.01143.x
Hon, Yuen Yi, Christine E. Chamberlain, David E. Kleiner, Michael S. Ring, Douglas A. Hale, Allan D. Kirk, and Roslyn B. Mannon. “Evaluation of tacrolimus abbreviated area-under-the-curve monitoring in renal transplant patients who are potentially at risk for adverse events.Clin Transplant 24, no. 4 (2010): 557–63. https://doi.org/10.1111/j.1399-0012.2009.01143.x.
Hon YY, Chamberlain CE, Kleiner DE, Ring MS, Hale DA, Kirk AD, et al. Evaluation of tacrolimus abbreviated area-under-the-curve monitoring in renal transplant patients who are potentially at risk for adverse events. Clin Transplant. 2010;24(4):557–63.
Hon, Yuen Yi, et al. “Evaluation of tacrolimus abbreviated area-under-the-curve monitoring in renal transplant patients who are potentially at risk for adverse events.Clin Transplant, vol. 24, no. 4, 2010, pp. 557–63. Pubmed, doi:10.1111/j.1399-0012.2009.01143.x.
Hon YY, Chamberlain CE, Kleiner DE, Ring MS, Hale DA, Kirk AD, Mannon RB. Evaluation of tacrolimus abbreviated area-under-the-curve monitoring in renal transplant patients who are potentially at risk for adverse events. Clin Transplant. 2010;24(4):557–563.
Journal cover image

Published In

Clin Transplant

DOI

EISSN

1399-0012

Publication Date

2010

Volume

24

Issue

4

Start / End Page

557 / 563

Location

Denmark

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • Time Factors
  • Tacrolimus
  • Survival Rate
  • Surgery
  • Middle Aged
  • Male
  • Kidney Transplantation
  • Immunosuppressive Agents