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Differential effects of donor-specific alloantibody.

Publication ,  Journal Article
Turgeon, NA; Kirk, AD; Iwakoshi, NN
Published in: Transplant Rev (Orlando)
January 2009

Alloantigen exposure typically provokes an adaptive immune response that can foster rejection of transplanted organs, and these responses present the most formidable biological barrier to kidney transplantation. Although most cellular alloimmune responses can be therapeutically controlled with T-cell-specific immunosuppressants, humoral alloimmune responses remain relatively untamed. Importantly, humoral immunity, typically manifesting as allospecific antibody production, is increasingly recognized for its variable appearance after kidney transplantation. Indeed, the appearance of alloantibody can herald the onset of rapid and destructive antibody-mediated rejection or have no demonstrable acute effects. The factors determining the end result of alloantibody formation remain poorly understood. This review will discuss the breadth of alloantibody responses seen in clinical kidney transplantation and provide an overview of potential factors explaining the phenotypic variability associated with humoral alloimmunity. We propose several avenues ripe for future investigation including the influence of innate immune components and the potential influence of heterologous immune responses in determining the ultimate clinical import of an alloantibody response.

Duke Scholars

Published In

Transplant Rev (Orlando)

DOI

EISSN

1557-9816

Publication Date

January 2009

Volume

23

Issue

1

Start / End Page

25 / 33

Location

United States

Related Subject Headings

  • Treatment Failure
  • Tissue Donors
  • T-Lymphocytes
  • Surgery
  • Rituximab
  • Lung Transplantation
  • Liver Transplantation
  • Kidney Transplantation
  • Kidney Failure, Chronic
  • Isoantibodies
 

Citation

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ICMJE
MLA
NLM
Turgeon, N. A., Kirk, A. D., & Iwakoshi, N. N. (2009). Differential effects of donor-specific alloantibody. Transplant Rev (Orlando), 23(1), 25–33. https://doi.org/10.1016/j.trre.2008.08.001
Turgeon, Nicole A., Allan D. Kirk, and Neal N. Iwakoshi. “Differential effects of donor-specific alloantibody.Transplant Rev (Orlando) 23, no. 1 (January 2009): 25–33. https://doi.org/10.1016/j.trre.2008.08.001.
Turgeon NA, Kirk AD, Iwakoshi NN. Differential effects of donor-specific alloantibody. Transplant Rev (Orlando). 2009 Jan;23(1):25–33.
Turgeon, Nicole A., et al. “Differential effects of donor-specific alloantibody.Transplant Rev (Orlando), vol. 23, no. 1, Jan. 2009, pp. 25–33. Pubmed, doi:10.1016/j.trre.2008.08.001.
Turgeon NA, Kirk AD, Iwakoshi NN. Differential effects of donor-specific alloantibody. Transplant Rev (Orlando). 2009 Jan;23(1):25–33.
Journal cover image

Published In

Transplant Rev (Orlando)

DOI

EISSN

1557-9816

Publication Date

January 2009

Volume

23

Issue

1

Start / End Page

25 / 33

Location

United States

Related Subject Headings

  • Treatment Failure
  • Tissue Donors
  • T-Lymphocytes
  • Surgery
  • Rituximab
  • Lung Transplantation
  • Liver Transplantation
  • Kidney Transplantation
  • Kidney Failure, Chronic
  • Isoantibodies