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Objective, real-time, intraoperative assessment of renal perfusion using infrared imaging.

Publication ,  Journal Article
Gorbach, A; Simonton, D; Hale, DA; Swanson, SJ; Kirk, AD
Published in: Am J Transplant
August 2003

Allograft ischemia induces delayed graft function and is correlated with increasing rates of rejection. There is not currently a way to objectively measure the effects of ischemia in real-time, nor to relate therapies combating reperfusion injury with their intended effects. An infrared (IR) method utilizing a focal plane array detector camera was developed for real-time intraoperative IR imaging of renal allografts, and evaluated in a pilot trial to quantify perfusion in recipients of live (n = 8) and cadaveric donor (n = 5) allografts. Digital images were taken for 3-8 min postreperfusion. Image data were compared to ischemic time and allograft function to assess potential clinical relevance. Cold ischemic time ranged from 0.5 to 29 h and was bimodally distributed between living and cadaveric donors. Renal rewarming time (RT) as determined by IR imaging correlated with cold ischemic time (p < 0.001, R 2 = 0.81), and predicted the subsequent return of renal function with RT negatively correlated to the regression slopes of creatinine (p = 0.02, R 2 = 0.38) and BUN (p = 0.07, R 2 = 0.26). Intraoperative IR imaging noninvasively provides clinically relevant real-time whole kidney assessment of reperfusion. This technology may aide in the objective assessment of therapies designed to limit reperfusion injury, and allow for quantitative assessment of allograft ischemic damage.

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Published In

Am J Transplant

DOI

ISSN

1600-6135

Publication Date

August 2003

Volume

3

Issue

8

Start / End Page

988 / 993

Location

United States

Related Subject Headings

  • Surgery
  • Reperfusion
  • Renal Circulation
  • Kidney Transplantation
  • Kidney
  • Ischemia
  • Intraoperative Care
  • Infrared Rays
  • Humans
  • 3204 Immunology
 

Citation

APA
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Gorbach, A., Simonton, D., Hale, D. A., Swanson, S. J., & Kirk, A. D. (2003). Objective, real-time, intraoperative assessment of renal perfusion using infrared imaging. Am J Transplant, 3(8), 988–993. https://doi.org/10.1034/j.1600-6143.2003.00158.x
Gorbach, Alexander, Donna Simonton, Douglas A. Hale, S John Swanson, and Allan D. Kirk. “Objective, real-time, intraoperative assessment of renal perfusion using infrared imaging.Am J Transplant 3, no. 8 (August 2003): 988–93. https://doi.org/10.1034/j.1600-6143.2003.00158.x.
Gorbach A, Simonton D, Hale DA, Swanson SJ, Kirk AD. Objective, real-time, intraoperative assessment of renal perfusion using infrared imaging. Am J Transplant. 2003 Aug;3(8):988–93.
Gorbach, Alexander, et al. “Objective, real-time, intraoperative assessment of renal perfusion using infrared imaging.Am J Transplant, vol. 3, no. 8, Aug. 2003, pp. 988–93. Pubmed, doi:10.1034/j.1600-6143.2003.00158.x.
Gorbach A, Simonton D, Hale DA, Swanson SJ, Kirk AD. Objective, real-time, intraoperative assessment of renal perfusion using infrared imaging. Am J Transplant. 2003 Aug;3(8):988–993.
Journal cover image

Published In

Am J Transplant

DOI

ISSN

1600-6135

Publication Date

August 2003

Volume

3

Issue

8

Start / End Page

988 / 993

Location

United States

Related Subject Headings

  • Surgery
  • Reperfusion
  • Renal Circulation
  • Kidney Transplantation
  • Kidney
  • Ischemia
  • Intraoperative Care
  • Infrared Rays
  • Humans
  • 3204 Immunology