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Potential of costimulation-based therapies for composite tissue allotransplantation.

Publication ,  Journal Article
Elster, EA; Blair, PJ; Kirk, AD
Published in: Microsurgery
2000

Clinical success has not been routinely achieved for composite tissue allotransplantation (CTA). Although most of the technical details of CTA have been overcome, the immunological aspects of these procedures have proved complex. Many traumatic conditions requiring CTA contraindicate acute global immunosuppression. Moreover, the risk of long-term immunosuppression is difficult to reconcile with non-life-threatening defects that can be adequately palliated. Recently, several successful immunomodulating strategies have been introduced for solid organ transplantation. They include therapies that alter costimulatory signals at engraftment. One approach, using treatment with a monoclonal antibody directed against CD154, has shown promise in rodent and nonhuman primate models and is discussed as a potential strategy for CTAs.

Duke Scholars

Published In

Microsurgery

DOI

ISSN

0738-1085

Publication Date

2000

Volume

20

Issue

8

Start / End Page

430 / 434

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Transplantation Immunology
  • Tissue Transplantation
  • Surgery
  • Rats
  • Primates
  • Immunosuppressive Agents
  • Immunosuppression Therapy
  • Humans
  • Graft Rejection
 

Citation

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Chicago
ICMJE
MLA
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Elster, E. A., Blair, P. J., & Kirk, A. D. (2000). Potential of costimulation-based therapies for composite tissue allotransplantation. Microsurgery, 20(8), 430–434. https://doi.org/10.1002/1098-2752(2000)20:8<430::aid-micr14>3.0.co;2-k
Elster, E. A., P. J. Blair, and A. D. Kirk. “Potential of costimulation-based therapies for composite tissue allotransplantation.Microsurgery 20, no. 8 (2000): 430–34. https://doi.org/10.1002/1098-2752(2000)20:8<430::aid-micr14>3.0.co;2-k.
Elster EA, Blair PJ, Kirk AD. Potential of costimulation-based therapies for composite tissue allotransplantation. Microsurgery. 2000;20(8):430–4.
Elster, E. A., et al. “Potential of costimulation-based therapies for composite tissue allotransplantation.Microsurgery, vol. 20, no. 8, 2000, pp. 430–34. Pubmed, doi:10.1002/1098-2752(2000)20:8<430::aid-micr14>3.0.co;2-k.
Elster EA, Blair PJ, Kirk AD. Potential of costimulation-based therapies for composite tissue allotransplantation. Microsurgery. 2000;20(8):430–434.
Journal cover image

Published In

Microsurgery

DOI

ISSN

0738-1085

Publication Date

2000

Volume

20

Issue

8

Start / End Page

430 / 434

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Transplantation Immunology
  • Tissue Transplantation
  • Surgery
  • Rats
  • Primates
  • Immunosuppressive Agents
  • Immunosuppression Therapy
  • Humans
  • Graft Rejection