The future of organ and tissue transplantation: can T-cell costimulatory pathway modifiers revolutionize the prevention of graft rejection?
Publication
, Journal Article
Harlan, DM; Kirk, AD
Published in: JAMA
September 15, 1999
Transplantation therapies have revolutionized care for patients with endstage organ (kidney, liver, heart, lung, and pancreatic beta-cell) failure, yet significant problems persist with treatments designed to prevent graft rejection. Antirejection therapies are not always effective, must be taken daily, and are both expensive and associated with well-known toxic effects. Recent advances have suggested that the immune system has more self-regulatory capability than previously appreciated. In this review, we discuss immune system function and new therapeutic agents that modify so-called costimulatory receptor signaling to support transplant function without generally suppressing the immune system.
Duke Scholars
Published In
JAMA
DOI
ISSN
0098-7484
Publication Date
September 15, 1999
Volume
282
Issue
11
Start / End Page
1076 / 1082
Location
United States
Related Subject Headings
- Transplantation Immunology
- Tissue Transplantation
- T-Lymphocytes
- Organ Transplantation
- Membrane Glycoproteins
- Lymphocyte Activation
- Ligands
- Humans
- Graft Rejection
- General & Internal Medicine
Citation
APA
Chicago
ICMJE
MLA
NLM
Harlan, D. M., & Kirk, A. D. (1999). The future of organ and tissue transplantation: can T-cell costimulatory pathway modifiers revolutionize the prevention of graft rejection? JAMA, 282(11), 1076–1082. https://doi.org/10.1001/jama.282.11.1076
Harlan, D. M., and A. D. Kirk. “The future of organ and tissue transplantation: can T-cell costimulatory pathway modifiers revolutionize the prevention of graft rejection?” JAMA 282, no. 11 (September 15, 1999): 1076–82. https://doi.org/10.1001/jama.282.11.1076.
Harlan DM, Kirk AD. The future of organ and tissue transplantation: can T-cell costimulatory pathway modifiers revolutionize the prevention of graft rejection? JAMA. 1999 Sep 15;282(11):1076–82.
Harlan, D. M., and A. D. Kirk. “The future of organ and tissue transplantation: can T-cell costimulatory pathway modifiers revolutionize the prevention of graft rejection?” JAMA, vol. 282, no. 11, Sept. 1999, pp. 1076–82. Pubmed, doi:10.1001/jama.282.11.1076.
Harlan DM, Kirk AD. The future of organ and tissue transplantation: can T-cell costimulatory pathway modifiers revolutionize the prevention of graft rejection? JAMA. 1999 Sep 15;282(11):1076–1082.
Published In
JAMA
DOI
ISSN
0098-7484
Publication Date
September 15, 1999
Volume
282
Issue
11
Start / End Page
1076 / 1082
Location
United States
Related Subject Headings
- Transplantation Immunology
- Tissue Transplantation
- T-Lymphocytes
- Organ Transplantation
- Membrane Glycoproteins
- Lymphocyte Activation
- Ligands
- Humans
- Graft Rejection
- General & Internal Medicine