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The clinical relevance of alloantibody in liver transplantation.

Publication ,  Journal Article
Burghuber, CK; Roberts, TK; Knechtle, SJ
Published in: Transplant Rev (Orlando)
January 2015

The transplanted liver appears resistant to antibody-mediated injury compared to other transplanted organs such as kidney or heart. However, a growing number of reports suggest that alloantibody to the liver is associated with poorer outcomes. The data surrounding this field are unclear, and their interpretation remains controversial. Mechanistically, there is not a clear explanation for the liver's resistance to antibody-mediated injury, and the pathological criteria for antibody-mediated rejection (AMR) remain ill-defined. Furthermore, treatment of AMR is non-uniform. The field would benefit from better outcome data based on measurement of antibody at the time of transplantation and at the time of rejection. Consensus opinion regarding antibody and the liver might emerge with better standardization of antibody measurement and pathological definition of AMR.

Duke Scholars

Published In

Transplant Rev (Orlando)

DOI

EISSN

1557-9816

Publication Date

January 2015

Volume

29

Issue

1

Start / End Page

16 / 22

Location

United States

Related Subject Headings

  • Surgery
  • Liver Transplantation
  • Liver Failure
  • Isoantibodies
  • Immunologic Factors
  • Humans
  • Graft Rejection
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Burghuber, C. K., Roberts, T. K., & Knechtle, S. J. (2015). The clinical relevance of alloantibody in liver transplantation. Transplant Rev (Orlando), 29(1), 16–22. https://doi.org/10.1016/j.trre.2014.06.001
Burghuber, C. K., T. K. Roberts, and S. J. Knechtle. “The clinical relevance of alloantibody in liver transplantation.Transplant Rev (Orlando) 29, no. 1 (January 2015): 16–22. https://doi.org/10.1016/j.trre.2014.06.001.
Burghuber CK, Roberts TK, Knechtle SJ. The clinical relevance of alloantibody in liver transplantation. Transplant Rev (Orlando). 2015 Jan;29(1):16–22.
Burghuber, C. K., et al. “The clinical relevance of alloantibody in liver transplantation.Transplant Rev (Orlando), vol. 29, no. 1, Jan. 2015, pp. 16–22. Pubmed, doi:10.1016/j.trre.2014.06.001.
Burghuber CK, Roberts TK, Knechtle SJ. The clinical relevance of alloantibody in liver transplantation. Transplant Rev (Orlando). 2015 Jan;29(1):16–22.
Journal cover image

Published In

Transplant Rev (Orlando)

DOI

EISSN

1557-9816

Publication Date

January 2015

Volume

29

Issue

1

Start / End Page

16 / 22

Location

United States

Related Subject Headings

  • Surgery
  • Liver Transplantation
  • Liver Failure
  • Isoantibodies
  • Immunologic Factors
  • Humans
  • Graft Rejection
  • 3202 Clinical sciences
  • 1103 Clinical Sciences