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Correlation between human leukocyte antigen antibody production and serum creatinine in patients receiving sirolimus monotherapy after Campath-1H induction.

Publication ,  Journal Article
Cai, J; Terasaki, PI; Bloom, DD; Torrealba, JR; Friedl, A; Sollinger, HW; Knechtle, SJ
Published in: Transplantation
September 27, 2004

BACKGROUND: In this study, we determined whether Campath-1H induction followed by sirolimus monotherapy inhibited alloantibody production in renal transplantation. Second, we evaluated the correlation between human leukocyte antigen (HLA) antibody production and serum creatinine levels. METHODS: Sera were taken 1 to 24 months after transplantation from 24 patients treated with Campath-1H and sirolimus and tested for serum creatinine and HLA-specific antibody by using flow cytometry and enzyme-linked immunosorbent assay. RESULTS: Ten (42%) of the 24 patients treated with Campath-1H and sirolimus produced HLA antibodies. Six of these 10 developed both donor-specific antibodies (DSAs) and non-donor-specific antibodies (NDSAs), whereas only NDSAs were detected in the other four patients. In patients with biopsy-diagnosed humoral rejection (C4d+), serum levels of both DSA and NDSA significantly correlated with patient serum creatinine levels. Rejection treatment successfully reduced both DSAs and NDSAs and reversed humoral rejection. CONCLUSIONS: The numeric relationship between serum creatinine and DSA levels suggests a causal relationship between alloantibody and transplant rejection.

Duke Scholars

Published In

Transplantation

DOI

ISSN

0041-1337

Publication Date

September 27, 2004

Volume

78

Issue

6

Start / End Page

919 / 924

Location

United States

Related Subject Headings

  • Surgery
  • Sirolimus
  • Kidney Transplantation
  • Immunosuppressive Agents
  • Humans
  • Histocompatibility Antigens Class I
  • HLA-D Antigens
  • HLA Antigens
  • Graft Rejection
  • Flow Cytometry
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Cai, J., Terasaki, P. I., Bloom, D. D., Torrealba, J. R., Friedl, A., Sollinger, H. W., & Knechtle, S. J. (2004). Correlation between human leukocyte antigen antibody production and serum creatinine in patients receiving sirolimus monotherapy after Campath-1H induction. Transplantation, 78(6), 919–924. https://doi.org/10.1097/01.tp.0000134398.86243.81
Cai, Junchao, Paul I. Terasaki, Debra D. Bloom, Jose R. Torrealba, Andreas Friedl, Hans W. Sollinger, and Stuart J. Knechtle. “Correlation between human leukocyte antigen antibody production and serum creatinine in patients receiving sirolimus monotherapy after Campath-1H induction.Transplantation 78, no. 6 (September 27, 2004): 919–24. https://doi.org/10.1097/01.tp.0000134398.86243.81.
Cai J, Terasaki PI, Bloom DD, Torrealba JR, Friedl A, Sollinger HW, et al. Correlation between human leukocyte antigen antibody production and serum creatinine in patients receiving sirolimus monotherapy after Campath-1H induction. Transplantation. 2004 Sep 27;78(6):919–24.
Cai, Junchao, et al. “Correlation between human leukocyte antigen antibody production and serum creatinine in patients receiving sirolimus monotherapy after Campath-1H induction.Transplantation, vol. 78, no. 6, Sept. 2004, pp. 919–24. Pubmed, doi:10.1097/01.tp.0000134398.86243.81.
Cai J, Terasaki PI, Bloom DD, Torrealba JR, Friedl A, Sollinger HW, Knechtle SJ. Correlation between human leukocyte antigen antibody production and serum creatinine in patients receiving sirolimus monotherapy after Campath-1H induction. Transplantation. 2004 Sep 27;78(6):919–924.

Published In

Transplantation

DOI

ISSN

0041-1337

Publication Date

September 27, 2004

Volume

78

Issue

6

Start / End Page

919 / 924

Location

United States

Related Subject Headings

  • Surgery
  • Sirolimus
  • Kidney Transplantation
  • Immunosuppressive Agents
  • Humans
  • Histocompatibility Antigens Class I
  • HLA-D Antigens
  • HLA Antigens
  • Graft Rejection
  • Flow Cytometry