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Liver transplantation as definitive therapy for complications after arterial embolization for hepatic manifestations of hereditary hemorrhagic telangiectasia.

Publication ,  Journal Article
Odorico, JS; Hakim, MN; Becker, YT; Van der Werf, W; Musat, A; Knechtle, SJ; D'Alessandro, AM; Kalayoglu, M
Published in: Liver Transpl Surg
November 1998

Experience with hepatic artery embolization for the treatment of symptomatic hepatic arteriovenous malformations (AVMs) in Rendu-Osler-Weber disease is limited. We report 2 cases of hepatic AVMs that caused mesenteric angina-like symptoms that were treated with embolization. Both patients developed parenchymal and bile duct necrosis, intrahepatic bilomas, and refractory biliary sepsis, subsequently leading to liver failure. We hypothesize that the pathophysiological cause of biliary necrosis in this setting is similar to that which occurs in the setting of hepatic artery thrombosis of the liver allograft. Progressive liver failure in these patients was treated successfully by liver transplantation. Liver transplantation offers definitive therapy by removing the source of ongoing sepsis, restoring normal liver function, and eliminating the intrahepatic AV shunt.

Duke Scholars

Published In

Liver Transpl Surg

DOI

ISSN

1074-3022

Publication Date

November 1998

Volume

4

Issue

6

Start / End Page

483 / 490

Location

United States

Related Subject Headings

  • Telangiectasia, Hereditary Hemorrhagic
  • Surgery
  • Postoperative Complications
  • Necrosis
  • Middle Aged
  • Liver Transplantation
  • Liver Failure
  • Liver Abscess
  • Humans
  • Hepatic Artery
 

Citation

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Odorico, J. S., Hakim, M. N., Becker, Y. T., Van der Werf, W., Musat, A., Knechtle, S. J., … Kalayoglu, M. (1998). Liver transplantation as definitive therapy for complications after arterial embolization for hepatic manifestations of hereditary hemorrhagic telangiectasia. Liver Transpl Surg, 4(6), 483–490. https://doi.org/10.1002/lt.500040609
Odorico, J. S., M. N. Hakim, Y. T. Becker, W. Van der Werf, A. Musat, S. J. Knechtle, A. M. D’Alessandro, and M. Kalayoglu. “Liver transplantation as definitive therapy for complications after arterial embolization for hepatic manifestations of hereditary hemorrhagic telangiectasia.Liver Transpl Surg 4, no. 6 (November 1998): 483–90. https://doi.org/10.1002/lt.500040609.
Odorico JS, Hakim MN, Becker YT, Van der Werf W, Musat A, Knechtle SJ, et al. Liver transplantation as definitive therapy for complications after arterial embolization for hepatic manifestations of hereditary hemorrhagic telangiectasia. Liver Transpl Surg. 1998 Nov;4(6):483–90.
Odorico, J. S., et al. “Liver transplantation as definitive therapy for complications after arterial embolization for hepatic manifestations of hereditary hemorrhagic telangiectasia.Liver Transpl Surg, vol. 4, no. 6, Nov. 1998, pp. 483–90. Pubmed, doi:10.1002/lt.500040609.
Odorico JS, Hakim MN, Becker YT, Van der Werf W, Musat A, Knechtle SJ, D’Alessandro AM, Kalayoglu M. Liver transplantation as definitive therapy for complications after arterial embolization for hepatic manifestations of hereditary hemorrhagic telangiectasia. Liver Transpl Surg. 1998 Nov;4(6):483–490.

Published In

Liver Transpl Surg

DOI

ISSN

1074-3022

Publication Date

November 1998

Volume

4

Issue

6

Start / End Page

483 / 490

Location

United States

Related Subject Headings

  • Telangiectasia, Hereditary Hemorrhagic
  • Surgery
  • Postoperative Complications
  • Necrosis
  • Middle Aged
  • Liver Transplantation
  • Liver Failure
  • Liver Abscess
  • Humans
  • Hepatic Artery