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Biomarkers of NAFLD progression: a lipidomics approach to an epidemic.

Publication ,  Journal Article
Gorden, DL; Myers, DS; Ivanova, PT; Fahy, E; Maurya, MR; Gupta, S; Min, J; Spann, NJ; McDonald, JG; Kelly, SL; Duan, J; Sullards, MC; Li, C ...
Published in: J Lipid Res
March 2015

The spectrum of nonalcoholic fatty liver disease (NAFLD) includes steatosis, nonalcoholic steatohepatitis (NASH), and cirrhosis. Recognition and timely diagnosis of these different stages, particularly NASH, is important for both potential reversibility and limitation of complications. Liver biopsy remains the clinical standard for definitive diagnosis. Diagnostic tools minimizing the need for invasive procedures or that add information to histologic data are important in novel management strategies for the growing epidemic of NAFLD. We describe an "omics" approach to detecting a reproducible signature of lipid metabolites, aqueous intracellular metabolites, SNPs, and mRNA transcripts in a double-blinded study of patients with different stages of NAFLD that involves profiling liver biopsies, plasma, and urine samples. Using linear discriminant analysis, a panel of 20 plasma metabolites that includes glycerophospholipids, sphingolipids, sterols, and various aqueous small molecular weight components involved in cellular metabolic pathways, can be used to differentiate between NASH and steatosis. This identification of differential biomolecular signatures has the potential to improve clinical diagnosis and facilitate therapeutic intervention of NAFLD.

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Published In

J Lipid Res

DOI

EISSN

1539-7262

Publication Date

March 2015

Volume

56

Issue

3

Start / End Page

722 / 736

Location

United States

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Non-alcoholic Fatty Liver Disease
  • Middle Aged
  • Male
  • Lipids
  • Humans
  • Female
  • Double-Blind Method
  • Biomarkers
  • Biochemistry & Molecular Biology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gorden, D. L., Myers, D. S., Ivanova, P. T., Fahy, E., Maurya, M. R., Gupta, S., … Brown, H. A. (2015). Biomarkers of NAFLD progression: a lipidomics approach to an epidemic. J Lipid Res, 56(3), 722–736. https://doi.org/10.1194/jlr.P056002
Gorden, D Lee, David S. Myers, Pavlina T. Ivanova, Eoin Fahy, Mano R. Maurya, Shakti Gupta, Jun Min, et al. “Biomarkers of NAFLD progression: a lipidomics approach to an epidemic.J Lipid Res 56, no. 3 (March 2015): 722–36. https://doi.org/10.1194/jlr.P056002.
Gorden DL, Myers DS, Ivanova PT, Fahy E, Maurya MR, Gupta S, et al. Biomarkers of NAFLD progression: a lipidomics approach to an epidemic. J Lipid Res. 2015 Mar;56(3):722–36.
Gorden, D. Lee, et al. “Biomarkers of NAFLD progression: a lipidomics approach to an epidemic.J Lipid Res, vol. 56, no. 3, Mar. 2015, pp. 722–36. Pubmed, doi:10.1194/jlr.P056002.
Gorden DL, Myers DS, Ivanova PT, Fahy E, Maurya MR, Gupta S, Min J, Spann NJ, McDonald JG, Kelly SL, Duan J, Sullards MC, Leiker TJ, Barkley RM, Quehenberger O, Armando AM, Milne SB, Mathews TP, Armstrong MD, Li C, Melvin WV, Clements RH, Washington MK, Mendonsa AM, Witztum JL, Guan Z, Glass CK, Murphy RC, Dennis EA, Merrill AH, Russell DW, Subramaniam S, Brown HA. Biomarkers of NAFLD progression: a lipidomics approach to an epidemic. J Lipid Res. 2015 Mar;56(3):722–736.

Published In

J Lipid Res

DOI

EISSN

1539-7262

Publication Date

March 2015

Volume

56

Issue

3

Start / End Page

722 / 736

Location

United States

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Non-alcoholic Fatty Liver Disease
  • Middle Aged
  • Male
  • Lipids
  • Humans
  • Female
  • Double-Blind Method
  • Biomarkers
  • Biochemistry & Molecular Biology