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Standardized beam bouquets for lung IMRT planning.

Publication ,  Journal Article
Yuan, L; Wu, QJ; Yin, F; Li, Y; Sheng, Y; Kelsey, CR; Ge, Y
Published in: Phys Med Biol
March 7, 2015

The selection of the incident angles of the treatment beams is a critical component of intensity modulated radiation therapy (IMRT) planning for lung cancer due to significant variations in tumor location, tumor size and patient anatomy. We investigate the feasibility of establishing a small set of standardized beam bouquets for planning. The set of beam bouquets were determined by learning the beam configuration features from 60 clinical lung IMRT plans designed by experienced planners. A k-medoids cluster analysis method was used to classify the beam configurations in the dataset. The appropriate number of clusters was determined by maximizing the value of average silhouette width of the classification. Once the number of clusters had been determined, the beam arrangements in each medoid of the clusters were designated as the standardized beam bouquet for the cluster. This standardized bouquet set was used to re-plan 20 cases randomly selected from the clinical database. The dosimetric quality of the plans using the beam bouquets was evaluated against the corresponding clinical plans by a paired t-test. The classification with six clusters has the largest average silhouette width value and hence would best represent the beam bouquet patterns in the dataset. The results shows that plans generated with a small number of standardized bouquets (e.g. 6) have comparable quality to that of clinical plans. These standardized beam configuration bouquets will potentially help improve plan efficiency and facilitate automated planning.

Duke Scholars

Published In

Phys Med Biol

DOI

EISSN

1361-6560

Publication Date

March 7, 2015

Volume

60

Issue

5

Start / End Page

1831 / 1843

Location

England

Related Subject Headings

  • Retrospective Studies
  • Radiotherapy, Intensity-Modulated
  • Radiotherapy Planning, Computer-Assisted
  • Radiometry
  • Physical Phenomena
  • Nuclear Medicine & Medical Imaging
  • Mediastinal Neoplasms
  • Lung Neoplasms
  • Humans
  • Algorithms
 

Citation

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Yuan, L., Wu, Q. J., Yin, F., Li, Y., Sheng, Y., Kelsey, C. R., & Ge, Y. (2015). Standardized beam bouquets for lung IMRT planning. Phys Med Biol, 60(5), 1831–1843. https://doi.org/10.1088/0031-9155/60/5/1831
Yuan, Lulin, Q Jackie Wu, Fangfang Yin, Ying Li, Yang Sheng, Christopher R. Kelsey, and Yaorong Ge. “Standardized beam bouquets for lung IMRT planning.Phys Med Biol 60, no. 5 (March 7, 2015): 1831–43. https://doi.org/10.1088/0031-9155/60/5/1831.
Yuan L, Wu QJ, Yin F, Li Y, Sheng Y, Kelsey CR, et al. Standardized beam bouquets for lung IMRT planning. Phys Med Biol. 2015 Mar 7;60(5):1831–43.
Yuan, Lulin, et al. “Standardized beam bouquets for lung IMRT planning.Phys Med Biol, vol. 60, no. 5, Mar. 2015, pp. 1831–43. Pubmed, doi:10.1088/0031-9155/60/5/1831.
Yuan L, Wu QJ, Yin F, Li Y, Sheng Y, Kelsey CR, Ge Y. Standardized beam bouquets for lung IMRT planning. Phys Med Biol. 2015 Mar 7;60(5):1831–1843.
Journal cover image

Published In

Phys Med Biol

DOI

EISSN

1361-6560

Publication Date

March 7, 2015

Volume

60

Issue

5

Start / End Page

1831 / 1843

Location

England

Related Subject Headings

  • Retrospective Studies
  • Radiotherapy, Intensity-Modulated
  • Radiotherapy Planning, Computer-Assisted
  • Radiometry
  • Physical Phenomena
  • Nuclear Medicine & Medical Imaging
  • Mediastinal Neoplasms
  • Lung Neoplasms
  • Humans
  • Algorithms