Rational opioid dosing in the elderly: dose and dosing interval when initiating opioid therapy.
Publication
, Journal Article
Gupta, DK; Avram, MJ
Published in: Clin Pharmacol Ther
February 2012
Opioids are the mainstay of treatment for moderate to severe pain. However, opioid therapy in the elderly is often associated with significant morbidity because of excessive ventilatory depression. The large amount of interindividual variability in opioid dose-response relationships makes it difficult to individualize the dose and dosing interval to provide safe and effective analgesia. By examining how aging affects the pharmacokinetics (PK) and pharmacodynamics (PD) of opioids, it is possible to provide a rational basis for age adjustment in opioid dosing.
Duke Scholars
Published In
Clin Pharmacol Ther
DOI
EISSN
1532-6535
Publication Date
February 2012
Volume
91
Issue
2
Start / End Page
339 / 343
Location
United States
Related Subject Headings
- Pharmacology & Pharmacy
- Pain Management
- Humans
- Drug Dosage Calculations
- Drug Administration Schedule
- Dose-Response Relationship, Drug
- Delayed-Action Preparations
- Analgesics, Opioid
- Aged, 80 and over
- Aged
Citation
APA
Chicago
ICMJE
MLA
NLM
Gupta, D. K., & Avram, M. J. (2012). Rational opioid dosing in the elderly: dose and dosing interval when initiating opioid therapy. Clin Pharmacol Ther, 91(2), 339–343. https://doi.org/10.1038/clpt.2011.307
Gupta, D. K., and M. J. Avram. “Rational opioid dosing in the elderly: dose and dosing interval when initiating opioid therapy.” Clin Pharmacol Ther 91, no. 2 (February 2012): 339–43. https://doi.org/10.1038/clpt.2011.307.
Gupta DK, Avram MJ. Rational opioid dosing in the elderly: dose and dosing interval when initiating opioid therapy. Clin Pharmacol Ther. 2012 Feb;91(2):339–43.
Gupta, D. K., and M. J. Avram. “Rational opioid dosing in the elderly: dose and dosing interval when initiating opioid therapy.” Clin Pharmacol Ther, vol. 91, no. 2, Feb. 2012, pp. 339–43. Pubmed, doi:10.1038/clpt.2011.307.
Gupta DK, Avram MJ. Rational opioid dosing in the elderly: dose and dosing interval when initiating opioid therapy. Clin Pharmacol Ther. 2012 Feb;91(2):339–343.
Published In
Clin Pharmacol Ther
DOI
EISSN
1532-6535
Publication Date
February 2012
Volume
91
Issue
2
Start / End Page
339 / 343
Location
United States
Related Subject Headings
- Pharmacology & Pharmacy
- Pain Management
- Humans
- Drug Dosage Calculations
- Drug Administration Schedule
- Dose-Response Relationship, Drug
- Delayed-Action Preparations
- Analgesics, Opioid
- Aged, 80 and over
- Aged