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Astrocytes Control Synapse Formation, Function, and Elimination.

Publication ,  Journal Article
Chung, W-S; Allen, NJ; Eroglu, C
Published in: Cold Spring Harb Perspect Biol
February 6, 2015

Astrocytes, through their close associations with synapses, can monitor and alter synaptic function, thus actively controlling synaptic transmission in the adult brain. Besides their important role at adult synapses, in the last three decades a number of critical findings have highlighted the importance of astrocytes in the establishment of synaptic connectivity in the developing brain. In this article, we will review the key findings on astrocytic control of synapse formation, function, and elimination. First, we will summarize our current structural and functional understanding of astrocytes at the synapse. Then, we will discuss the cellular and molecular mechanisms through which developing and mature astrocytes instruct the formation, maturation, and refinement of synapses. Our aim is to provide an overview of astrocytes as important players in the establishment of a functional nervous system.

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Published In

Cold Spring Harb Perspect Biol

DOI

EISSN

1943-0264

Publication Date

February 6, 2015

Volume

7

Issue

9

Start / End Page

a020370

Location

United States

Related Subject Headings

  • Synapses
  • Humans
  • Astrocytes
  • Animals
  • 3105 Genetics
  • 3101 Biochemistry and cell biology
 

Citation

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Chung, W.-S., Allen, N. J., & Eroglu, C. (2015). Astrocytes Control Synapse Formation, Function, and Elimination. Cold Spring Harb Perspect Biol, 7(9), a020370. https://doi.org/10.1101/cshperspect.a020370
Chung, Won-Suk, Nicola J. Allen, and Cagla Eroglu. “Astrocytes Control Synapse Formation, Function, and Elimination.Cold Spring Harb Perspect Biol 7, no. 9 (February 6, 2015): a020370. https://doi.org/10.1101/cshperspect.a020370.
Chung W-S, Allen NJ, Eroglu C. Astrocytes Control Synapse Formation, Function, and Elimination. Cold Spring Harb Perspect Biol. 2015 Feb 6;7(9):a020370.
Chung, Won-Suk, et al. “Astrocytes Control Synapse Formation, Function, and Elimination.Cold Spring Harb Perspect Biol, vol. 7, no. 9, Feb. 2015, p. a020370. Pubmed, doi:10.1101/cshperspect.a020370.
Chung W-S, Allen NJ, Eroglu C. Astrocytes Control Synapse Formation, Function, and Elimination. Cold Spring Harb Perspect Biol. 2015 Feb 6;7(9):a020370.

Published In

Cold Spring Harb Perspect Biol

DOI

EISSN

1943-0264

Publication Date

February 6, 2015

Volume

7

Issue

9

Start / End Page

a020370

Location

United States

Related Subject Headings

  • Synapses
  • Humans
  • Astrocytes
  • Animals
  • 3105 Genetics
  • 3101 Biochemistry and cell biology