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An investigation of PRESAGE® 3D dosimetry for IMRT and VMAT radiation therapy treatment verification.

Publication ,  Journal Article
Jackson, J; Juang, T; Adamovics, J; Oldham, M
Published in: Phys Med Biol
March 21, 2015

The purpose of this work was to characterize three formulations of PRESAGE(®) dosimeters (DEA-1, DEA-2, and DX) and to identify optimal readout timing and procedures for accurate in-house 3D dosimetry. The optimal formulation and procedure was then applied for the verification of an intensity modulated radiation therapy (IMRT) and a volumetric modulated arc therapy (VMAT) treatment technique. PRESAGE(®) formulations were studied for their temporal stability post-irradiation, sensitivity, and linearity of dose response. Dosimeters were read out using a high-resolution optical-CT scanner. Small volumes of PRESAGE(®) were irradiated to investigate possible differences in sensitivity for large and small volumes ('volume effect'). The optimal formulation and read-out technique was applied to the verification of two patient treatments: an IMRT plan and a VMAT plan. A gradual decrease in post-irradiation optical-density was observed in all formulations with DEA-1 exhibiting the best temporal stability with less than 4% variation between 2-22 h post-irradiation. A linear dose response at the 4 h time point was observed for all formulations with an R(2) value >0.99. A large volume effect was observed for DEA-1 with sensitivity of the large dosimeter being ~63% less than the sensitivity of the cuvettes. For the IMRT and VMAT treatments, the 3D gamma passing rates for 3%/3 mm criteria using absolute measured dose were 99.6 and 94.5% for the IMRT and VMAT treatments, respectively. In summary, this work shows that accurate 3D dosimetry is possible with all three PRESAGE(®) formulations. The optimal imaging windows post-irradiation were 3-24 h, 2-6 h, and immediately for the DEA-1, DEA-2, and DX formulations, respectively. Because of the large volume effect, small volume cuvettes are not yet a reliable method for calibration of larger dosimeters to absolute dose. Finally, PRESAGE(®) is observed to be a useful method of 3D verification when careful consideration is given to the temporal stability and imaging protocols for the specific formulation used.

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Published In

Phys Med Biol

DOI

EISSN

1361-6560

Publication Date

March 21, 2015

Volume

60

Issue

6

Start / End Page

2217 / 2230

Location

England

Related Subject Headings

  • Tomography Scanners, X-Ray Computed
  • Radiotherapy, Intensity-Modulated
  • Radiotherapy Planning, Computer-Assisted
  • Radiotherapy Dosage
  • Radiation Monitoring
  • Nuclear Medicine & Medical Imaging
  • Humans
  • Gamma Rays
  • 5105 Medical and biological physics
  • 1103 Clinical Sciences
 

Citation

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Jackson, J., Juang, T., Adamovics, J., & Oldham, M. (2015). An investigation of PRESAGE® 3D dosimetry for IMRT and VMAT radiation therapy treatment verification. Phys Med Biol, 60(6), 2217–2230. https://doi.org/10.1088/0031-9155/60/6/2217
Jackson, Jake, Titania Juang, John Adamovics, and Mark Oldham. “An investigation of PRESAGE® 3D dosimetry for IMRT and VMAT radiation therapy treatment verification.Phys Med Biol 60, no. 6 (March 21, 2015): 2217–30. https://doi.org/10.1088/0031-9155/60/6/2217.
Jackson J, Juang T, Adamovics J, Oldham M. An investigation of PRESAGE® 3D dosimetry for IMRT and VMAT radiation therapy treatment verification. Phys Med Biol. 2015 Mar 21;60(6):2217–30.
Jackson, Jake, et al. “An investigation of PRESAGE® 3D dosimetry for IMRT and VMAT radiation therapy treatment verification.Phys Med Biol, vol. 60, no. 6, Mar. 2015, pp. 2217–30. Pubmed, doi:10.1088/0031-9155/60/6/2217.
Jackson J, Juang T, Adamovics J, Oldham M. An investigation of PRESAGE® 3D dosimetry for IMRT and VMAT radiation therapy treatment verification. Phys Med Biol. 2015 Mar 21;60(6):2217–2230.
Journal cover image

Published In

Phys Med Biol

DOI

EISSN

1361-6560

Publication Date

March 21, 2015

Volume

60

Issue

6

Start / End Page

2217 / 2230

Location

England

Related Subject Headings

  • Tomography Scanners, X-Ray Computed
  • Radiotherapy, Intensity-Modulated
  • Radiotherapy Planning, Computer-Assisted
  • Radiotherapy Dosage
  • Radiation Monitoring
  • Nuclear Medicine & Medical Imaging
  • Humans
  • Gamma Rays
  • 5105 Medical and biological physics
  • 1103 Clinical Sciences