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The complexities of Xpert® MTB/RIF interpretation.

Publication ,  Journal Article
Lippincott, CK; Miller, MB; Van Rie, A; Weber, DJ; Sena, AC; Stout, JE
Published in: Int J Tuberc Lung Dis
March 2015
Published version (DOI) Link to item

The Xpert(®) MTB/RIF assay has demonstrated robust capability for diagnosing tuberculosis (TB) and rifampin (RMP) resistance. Optimal use of Xpert in diverse settings will require knowledge of challenges when interpreting the results. We present three selected cases from the United States, a low-burden TB setting, to highlight important clinical scenarios encountered with Xpert testing: rapid RMP resistance detection in a patient with pre-extensively drug-resistant TB who immigrated from the Philippines, false-positive RMP resistance detection, and Mycobacterium tuberculosis detection in a culture-negative patient. These cases demonstrate that a low pre-test probability of TB or drug-resistant TB can complicate the interpretation of the Xpert assay.

Duke Scholars

Jason Eric Stout
Author Jason Eric Stout Medicine, Infectious Diseases
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Published In

Int J Tuberc Lung Dis

DOI

10.5588/ijtld.14.0432

EISSN

1815-7920

Publication Date

March 2015

Volume

19

Issue

3

Start / End Page

273 / 275

Location

France

Related Subject Headings

  • United States
  • Tuberculosis, Pulmonary
  • Tuberculosis, Multidrug-Resistant
  • Tuberculin Test
  • Treatment Outcome
  • Sputum
  • Specimen Handling
  • Rifampin
  • Nucleic Acid Amplification Techniques
  • Mycobacterium tuberculosis
 

Citation

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Lippincott, C. K., Miller, M. B., Van Rie, A., Weber, D. J., Sena, A. C., & Stout, J. E. (2015). The complexities of Xpert® MTB/RIF interpretation. Int J Tuberc Lung Dis, 19(3), 273–275. https://doi.org/10.5588/ijtld.14.0432
Lippincott, C. K., M. B. Miller, A. Van Rie, D. J. Weber, A. C. Sena, and J. E. Stout. “The complexities of Xpert® MTB/RIF interpretation.” Int J Tuberc Lung Dis 19, no. 3 (March 2015): 273–75. https://doi.org/10.5588/ijtld.14.0432.
Lippincott CK, Miller MB, Van Rie A, Weber DJ, Sena AC, Stout JE. The complexities of Xpert® MTB/RIF interpretation. Int J Tuberc Lung Dis. 2015 Mar;19(3):273–5.
Lippincott, C. K., et al. “The complexities of Xpert® MTB/RIF interpretation.” Int J Tuberc Lung Dis, vol. 19, no. 3, Mar. 2015, pp. 273–75. Pubmed, doi:10.5588/ijtld.14.0432.
Lippincott CK, Miller MB, Van Rie A, Weber DJ, Sena AC, Stout JE. The complexities of Xpert® MTB/RIF interpretation. Int J Tuberc Lung Dis. 2015 Mar;19(3):273–275.

Published In

Int J Tuberc Lung Dis

DOI

10.5588/ijtld.14.0432

EISSN

1815-7920

Publication Date

March 2015

Volume

19

Issue

3

Start / End Page

273 / 275

Location

France

Related Subject Headings

  • United States
  • Tuberculosis, Pulmonary
  • Tuberculosis, Multidrug-Resistant
  • Tuberculin Test
  • Treatment Outcome
  • Sputum
  • Specimen Handling
  • Rifampin
  • Nucleic Acid Amplification Techniques
  • Mycobacterium tuberculosis