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Moving upstream in the war on WNTs.

Publication ,  Journal Article
Virshup, DM
Published in: J Clin Invest
March 2, 2015

Cholangiocarcinoma is a relatively rare cancer of the biliary ducts that is highly refractory to treatment. The factors that drive cholangiocarcinoma are poorly understood, though chronic liver fluke infection is a risk factor for disease. In this issue of the JCI, Boulter and colleagues demonstrate that the WNT/β-catenin signaling pathway is upregulated in patients with sporadic cholangiocarcinoma. The authors determined that macrophages generate WNT ligands in cholangiocarcinomas and depletion or inhibition of this cell population in animal models of cholangiocarcinoma reduced tumor burden and proliferation. Moreover, pharmacological inhibition of WNT secretion or β-catenin activity was efficacious in animal models. Together the results of this study suggest that targeting WNT has potential as a therapeutic strategy for cholangiocarcinoma.

Duke Scholars

Published In

J Clin Invest

DOI

EISSN

1558-8238

Publication Date

March 2, 2015

Volume

125

Issue

3

Start / End Page

975 / 977

Location

United States

Related Subject Headings

  • Wnt Signaling Pathway
  • Pyrimidinones
  • Pyridines
  • Male
  • Immunology
  • Humans
  • Cholangiocarcinoma
  • Bridged Bicyclo Compounds, Heterocyclic
  • Bile Ducts, Intrahepatic
  • Bile Duct Neoplasms
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Virshup, D. M. (2015). Moving upstream in the war on WNTs. J Clin Invest, 125(3), 975–977. https://doi.org/10.1172/JCI80819
Virshup, David M. “Moving upstream in the war on WNTs.J Clin Invest 125, no. 3 (March 2, 2015): 975–77. https://doi.org/10.1172/JCI80819.
Virshup DM. Moving upstream in the war on WNTs. J Clin Invest. 2015 Mar 2;125(3):975–7.
Virshup, David M. “Moving upstream in the war on WNTs.J Clin Invest, vol. 125, no. 3, Mar. 2015, pp. 975–77. Pubmed, doi:10.1172/JCI80819.
Virshup DM. Moving upstream in the war on WNTs. J Clin Invest. 2015 Mar 2;125(3):975–977.

Published In

J Clin Invest

DOI

EISSN

1558-8238

Publication Date

March 2, 2015

Volume

125

Issue

3

Start / End Page

975 / 977

Location

United States

Related Subject Headings

  • Wnt Signaling Pathway
  • Pyrimidinones
  • Pyridines
  • Male
  • Immunology
  • Humans
  • Cholangiocarcinoma
  • Bridged Bicyclo Compounds, Heterocyclic
  • Bile Ducts, Intrahepatic
  • Bile Duct Neoplasms