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Feedback in the brainstem: an excitatory disynaptic pathway for control of whisking.

Publication ,  Journal Article
Matthews, DW; Deschênes, M; Furuta, T; Moore, JD; Wang, F; Karten, HJ; Kleinfeld, D
Published in: J Comp Neurol
April 15, 2015

Sensorimotor processing relies on hierarchical neuronal circuits to mediate sensory-driven behaviors. In the mouse vibrissa system, trigeminal brainstem circuits are thought to mediate the first stage of vibrissa scanning control via sensory feedback that provides reflexive protraction in response to stimulation. However, these circuits are not well defined. Here we describe a complete disynaptic sensory receptor-to-muscle circuit for positive feedback in vibrissa movement. We identified a novel region of trigeminal brainstem, spinal trigeminal nucleus pars muralis, which contains a class of vGluT2+ excitatory projection neurons involved in vibrissa motor control. Complementary single- and dual-labeling with traditional and virus tracers demonstrate that these neurons both receive primary inputs from vibrissa sensory afferent fibers and send monosynaptic connections to facial nucleus motoneurons that directly innervate vibrissa musculature. These anatomical results suggest a general role of disynaptic architecture in fast positive feedback for motor output that drives active sensation.

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Published In

J Comp Neurol

DOI

EISSN

1096-9861

Publication Date

April 15, 2015

Volume

523

Issue

6

Start / End Page

921 / 942

Location

United States

Related Subject Headings

  • Vibrissae
  • Vesicular Inhibitory Amino Acid Transport Proteins
  • Vesicular Glutamate Transport Protein 2
  • Vagus Nerve
  • Synapses
  • Spinal Cord
  • Reflex
  • Neurons
  • Neurology & Neurosurgery
  • Mice, Transgenic
 

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Matthews, D. W., Deschênes, M., Furuta, T., Moore, J. D., Wang, F., Karten, H. J., & Kleinfeld, D. (2015). Feedback in the brainstem: an excitatory disynaptic pathway for control of whisking. J Comp Neurol, 523(6), 921–942. https://doi.org/10.1002/cne.23724
Matthews, David W., Martin Deschênes, Takahiro Furuta, Jeffrey D. Moore, Fan Wang, Harvey J. Karten, and David Kleinfeld. “Feedback in the brainstem: an excitatory disynaptic pathway for control of whisking.J Comp Neurol 523, no. 6 (April 15, 2015): 921–42. https://doi.org/10.1002/cne.23724.
Matthews DW, Deschênes M, Furuta T, Moore JD, Wang F, Karten HJ, et al. Feedback in the brainstem: an excitatory disynaptic pathway for control of whisking. J Comp Neurol. 2015 Apr 15;523(6):921–42.
Matthews, David W., et al. “Feedback in the brainstem: an excitatory disynaptic pathway for control of whisking.J Comp Neurol, vol. 523, no. 6, Apr. 2015, pp. 921–42. Pubmed, doi:10.1002/cne.23724.
Matthews DW, Deschênes M, Furuta T, Moore JD, Wang F, Karten HJ, Kleinfeld D. Feedback in the brainstem: an excitatory disynaptic pathway for control of whisking. J Comp Neurol. 2015 Apr 15;523(6):921–942.
Journal cover image

Published In

J Comp Neurol

DOI

EISSN

1096-9861

Publication Date

April 15, 2015

Volume

523

Issue

6

Start / End Page

921 / 942

Location

United States

Related Subject Headings

  • Vibrissae
  • Vesicular Inhibitory Amino Acid Transport Proteins
  • Vesicular Glutamate Transport Protein 2
  • Vagus Nerve
  • Synapses
  • Spinal Cord
  • Reflex
  • Neurons
  • Neurology & Neurosurgery
  • Mice, Transgenic