Association of intracranial aneurysm and Loeys-Dietz syndrome: case illustration, management, and literature review.
BACKGROUND AND IMPORTANCE: Loeys-Dietz syndrome (LDS) is a newly described connective tissue disease associated with aortic aneurysms. A strong association between LDS and intracranial aneurysms has not yet been documented in the literature. We present the first detailed report of an intracranial aneurysm finding in an LDS patient. CLINICAL PRESENTATION: The patient is a 20-year-old female recently diagnosed with LDS and found to harbor 2 incidental intracranial aneurysms on a screening magnetic resonance angiography: a 3-mm right carotid ophthalmic aneurysm and an 8-mm partially fusiform paraclinoid carotid artery aneurysm. A standard left pterional craniotomy was performed. Intraoperative adenosine was used instead of temporary clipping because her vessels were extremely friable. After reconstruction, an intraoperative indocyanine green angiogram was obtained, confirming complete aneurysmal obliteration and internal carotid artery patency. CONCLUSION: This is the first detailed report of a clear association between intracranial aneurysms and LDS. An association between LDS and intracranial aneurysms, if substantiated in a larger study, has implications for aneurysm screening in this population. Such an association may shed light on mechanisms of aneurysm formation, growth, and rupture.
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Related Subject Headings
- Young Adult
- Neurology & Neurosurgery
- Magnetic Resonance Angiography
- Loeys-Dietz Syndrome
- Intracranial Aneurysm
- Humans
- Female
- Craniotomy
- Carotid Artery Diseases
- 5202 Biological psychology
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Young Adult
- Neurology & Neurosurgery
- Magnetic Resonance Angiography
- Loeys-Dietz Syndrome
- Intracranial Aneurysm
- Humans
- Female
- Craniotomy
- Carotid Artery Diseases
- 5202 Biological psychology