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Neovascular events in eyes with central retinal vein occlusion undergoing serial bevacizumab or ranibizumab intravitreal injections: a retrospective review.

Publication ,  Journal Article
DeCroos, FC; Todorich, B; Alshareef, R; Khuthaila, M; Fekrat, S; Ho, AC; Regillo, CD; Spirn, MJ
Published in: J Ophthalmic Vis Res
2014

PURPOSE: To characterize the onset and type of neovascular events in eyes with central retinal vein occlusion (CRVO) undergoing serial anti-VEGF therapy. METHODS: Consecutive eyes undergoing serial intravitreal bevacizumab or ranibizumab injections for treatment of CME secondary to CRVO were identified. Pertinent data was retrospectively collected and included type and onset of the neovascular event, and the treatment free interval from last injection until the neovascular event. Kaplan-Meier life table analysis was performed to determine the differential effects of baseline perfusion status, early initiation of anti-VEGF treatment (within 3 months of CRVO onset) versus later treatment, and continuous (1-month±2 weeks) versus discontinuous treatment interval (>1.5 months) on time until neovascular event. RESULTS: Of 31 eligible eyes, 12 (39%) and 19 (61%) presented with perfused and ischemic CRVO, respectively. The mean duration from CRVO until the onset of any neovascular event was 17.0±10.3 months. The mean treatment-free interval prior to any neovascular event was 6.2±7.3 months. On average, 5.3±3.2 anti-VEGF injections were given prior to any neovascular event. Neovascularization of the iris or angle occurred in 18 eyes (58%), vitreous hemorrhage associated with neovascularization was observed in 9 eyes (29%) and neovascularization of the disc developed in 5 eyes (16%). Neovascular events showed a trend towards occurring later in eyes with perfused CRVO at baseline (log rank test, P=0.07). CONCLUSION: Neovascular events occur in eyes with CRVO undergoing serial anti-VEGF therapy, and these events may be delayed compared to the natural history of CRVO-associated neovascularization. Iris neovascularization occurred most frequently.

Duke Scholars

Published In

J Ophthalmic Vis Res

DOI

ISSN

2008-2010

Publication Date

2014

Volume

9

Issue

4

Start / End Page

461 / 468

Location

United Arab Emirates

Related Subject Headings

  • 3212 Ophthalmology and optometry
  • 1113 Opthalmology and Optometry
 

Citation

APA
Chicago
ICMJE
MLA
NLM
DeCroos, F. C., Todorich, B., Alshareef, R., Khuthaila, M., Fekrat, S., Ho, A. C., … Spirn, M. J. (2014). Neovascular events in eyes with central retinal vein occlusion undergoing serial bevacizumab or ranibizumab intravitreal injections: a retrospective review. J Ophthalmic Vis Res, 9(4), 461–468. https://doi.org/10.4103/2008-322X.150825
DeCroos, Francis Char, Bozho Todorich, Rayan Alshareef, Mohammed Khuthaila, Sharon Fekrat, Allen C. Ho, Carl D. Regillo, and Marc J. Spirn. “Neovascular events in eyes with central retinal vein occlusion undergoing serial bevacizumab or ranibizumab intravitreal injections: a retrospective review.J Ophthalmic Vis Res 9, no. 4 (2014): 461–68. https://doi.org/10.4103/2008-322X.150825.
DeCroos FC, Todorich B, Alshareef R, Khuthaila M, Fekrat S, Ho AC, et al. Neovascular events in eyes with central retinal vein occlusion undergoing serial bevacizumab or ranibizumab intravitreal injections: a retrospective review. J Ophthalmic Vis Res. 2014;9(4):461–8.
DeCroos, Francis Char, et al. “Neovascular events in eyes with central retinal vein occlusion undergoing serial bevacizumab or ranibizumab intravitreal injections: a retrospective review.J Ophthalmic Vis Res, vol. 9, no. 4, 2014, pp. 461–68. Pubmed, doi:10.4103/2008-322X.150825.
DeCroos FC, Todorich B, Alshareef R, Khuthaila M, Fekrat S, Ho AC, Regillo CD, Spirn MJ. Neovascular events in eyes with central retinal vein occlusion undergoing serial bevacizumab or ranibizumab intravitreal injections: a retrospective review. J Ophthalmic Vis Res. 2014;9(4):461–468.

Published In

J Ophthalmic Vis Res

DOI

ISSN

2008-2010

Publication Date

2014

Volume

9

Issue

4

Start / End Page

461 / 468

Location

United Arab Emirates

Related Subject Headings

  • 3212 Ophthalmology and optometry
  • 1113 Opthalmology and Optometry