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Factors impacting survival in children with renal cell carcinoma.

Publication ,  Journal Article
Rialon, KL; Gulack, BC; Englum, BR; Routh, JC; Rice, HE
Published in: J Pediatr Surg
June 2015

PURPOSE: Renal cell carcinoma (RCC) is an uncommon tumor in the pediatric population. We examined a large national cancer database to determine outcomes for children with RCC and to identify variables affecting long-term survival. METHODS: The National Cancer Data Base (NCDB) was queried for patients age 0 to 17 years diagnosed with RCC from 1998-2011. Patient demographics, tumor stage and characteristics, management, and outcomes were evaluated. RESULTS: A total of 304 children met inclusion criteria. Overall, 39% of children had stage I disease, 16% stage II, 33% stage III, and 12% stage IV. One-year and five-year survival for all children was 87% and 70%, respectively. Eighty-six percent of patients underwent surgical resection. In comparison to children who underwent complete nephrectomy, patients undergoing partial nephrectomy had smaller tumors and were of lower clinical stages. Survival following partial resection was 100% at one and five years. Age and gender had no significant impact on survival. Survival was negatively impacted by increasing tumor size (P<0.001), positive nodal status (P=0.001), and higher pathologic stage (P<0.001). CONCLUSION: Children with renal cell carcinoma who undergo surgical resection have excellent one-year and five-year survival. Overall survival is significantly affected by pathologic stage, tumor size, and nodal status.

Published In

J Pediatr Surg

DOI

EISSN

1531-5037

Publication Date

June 2015

Volume

50

Issue

6

Start / End Page

1014 / 1018

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Survival Rate
  • Risk Factors
  • Pediatrics
  • Nephrectomy
  • Neoplasm Staging
  • Male
  • Kidney Neoplasms
  • Infant, Newborn
  • Infant
 

Citation

APA
Chicago
ICMJE
MLA
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Rialon, K. L., Gulack, B. C., Englum, B. R., Routh, J. C., & Rice, H. E. (2015). Factors impacting survival in children with renal cell carcinoma. J Pediatr Surg, 50(6), 1014–1018. https://doi.org/10.1016/j.jpedsurg.2015.03.027
Rialon, Kristy L., Brian C. Gulack, Brian R. Englum, Jonathan C. Routh, and Henry E. Rice. “Factors impacting survival in children with renal cell carcinoma.J Pediatr Surg 50, no. 6 (June 2015): 1014–18. https://doi.org/10.1016/j.jpedsurg.2015.03.027.
Rialon KL, Gulack BC, Englum BR, Routh JC, Rice HE. Factors impacting survival in children with renal cell carcinoma. J Pediatr Surg. 2015 Jun;50(6):1014–8.
Rialon, Kristy L., et al. “Factors impacting survival in children with renal cell carcinoma.J Pediatr Surg, vol. 50, no. 6, June 2015, pp. 1014–18. Pubmed, doi:10.1016/j.jpedsurg.2015.03.027.
Rialon KL, Gulack BC, Englum BR, Routh JC, Rice HE. Factors impacting survival in children with renal cell carcinoma. J Pediatr Surg. 2015 Jun;50(6):1014–1018.
Journal cover image

Published In

J Pediatr Surg

DOI

EISSN

1531-5037

Publication Date

June 2015

Volume

50

Issue

6

Start / End Page

1014 / 1018

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Survival Rate
  • Risk Factors
  • Pediatrics
  • Nephrectomy
  • Neoplasm Staging
  • Male
  • Kidney Neoplasms
  • Infant, Newborn
  • Infant