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Phenolic diterpenoid derivatives as anti-influenza a virus agents.

Publication ,  Journal Article
Dang, Z; Jung, K; Zhu, L; Xie, H; Lee, K-H; Chen, C-H; Huang, L
Published in: ACS Med Chem Lett
March 12, 2015

A series of diterpenoid derivatives based on podocarpic acid were synthesized and evaluated as anti-influenza A virus agents. Several of the novel podocarpic acid derivatives exhibited nanomolar activities against an H1N1 influenza A virus (A/Puerto Rico/8/34) that was resistant to two anti-influenza drugs, oseltamivir and amantadine. This class of compounds inhibits the influenza virus by targeting the viral hemagglutinin-mediated membrane fusion. These results indicated that podocarpic acid derivatives may serve as potential drug candidates to fight drug-resistant influenza A virus infections.

Duke Scholars

Published In

ACS Med Chem Lett

DOI

ISSN

1948-5875

Publication Date

March 12, 2015

Volume

6

Issue

3

Start / End Page

355 / 358

Location

United States

Related Subject Headings

  • 3405 Organic chemistry
  • 3404 Medicinal and biomolecular chemistry
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 0305 Organic Chemistry
  • 0304 Medicinal and Biomolecular Chemistry
 

Citation

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MLA
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Dang, Z., Jung, K., Zhu, L., Xie, H., Lee, K.-H., Chen, C.-H., & Huang, L. (2015). Phenolic diterpenoid derivatives as anti-influenza a virus agents. ACS Med Chem Lett, 6(3), 355–358. https://doi.org/10.1021/ml500533x
Dang, Zhao, Katherine Jung, Lei Zhu, Hua Xie, Kuo-Hsiung Lee, Chin-Ho Chen, and Li Huang. “Phenolic diterpenoid derivatives as anti-influenza a virus agents.ACS Med Chem Lett 6, no. 3 (March 12, 2015): 355–58. https://doi.org/10.1021/ml500533x.
Dang Z, Jung K, Zhu L, Xie H, Lee K-H, Chen C-H, et al. Phenolic diterpenoid derivatives as anti-influenza a virus agents. ACS Med Chem Lett. 2015 Mar 12;6(3):355–8.
Dang, Zhao, et al. “Phenolic diterpenoid derivatives as anti-influenza a virus agents.ACS Med Chem Lett, vol. 6, no. 3, Mar. 2015, pp. 355–58. Pubmed, doi:10.1021/ml500533x.
Dang Z, Jung K, Zhu L, Xie H, Lee K-H, Chen C-H, Huang L. Phenolic diterpenoid derivatives as anti-influenza a virus agents. ACS Med Chem Lett. 2015 Mar 12;6(3):355–358.
Journal cover image

Published In

ACS Med Chem Lett

DOI

ISSN

1948-5875

Publication Date

March 12, 2015

Volume

6

Issue

3

Start / End Page

355 / 358

Location

United States

Related Subject Headings

  • 3405 Organic chemistry
  • 3404 Medicinal and biomolecular chemistry
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 0305 Organic Chemistry
  • 0304 Medicinal and Biomolecular Chemistry