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Deceased donor multidrug resistance protein 1 and caveolin 1 gene variants may influence allograft survival in kidney transplantation.

Publication ,  Journal Article
Ma, J; Divers, J; Palmer, ND; Julian, BA; Israni, AK; Schladt, D; Pastan, SO; Chattrabhuti, K; Gautreaux, MD; Hauptfeld, V; Bray, RA; Kirk, AD ...
Published in: Kidney Int
September 2015

Variants in donor multidrug resistance protein 1 (ABCB1) and caveolin 1 (CAV1) genes are associated with renal allograft failure after transplantation in Europeans. Here we assessed transplantation outcomes of kidneys from 368 African American (AA) and 314 European American (EA) deceased donors based on 38 single-nucleotide polymorphisms (SNPs) spanning ABCB1 and 16 SNPs spanning CAV1, including previously associated index and haplotype-tagging SNPs. Tests for association with time to allograft failure were performed for the 1233 resultant kidney transplantations, adjusting for recipient age, sex, ethnicity, cold ischemia time, panel reactive antibody, human leukocyte antigen match, expanded-criteria donation, and APOL1-nephropathy variants in AA donors. Interaction analyses between APOL1 with ABCB1 and CAV1 were performed. In a meta-analysis of all transplantations, ABCB1 index SNP rs1045642 was associated with time to allograft failure and other ABCB1 SNPs were nominally associated, but not CAV1 SNPs. ABCB1 SNP rs1045642 showed consistent effects with the 558 transplantations from EA donors, but not with the 675 transplantations from AA donors. ABCB1 SNP rs956825 and CAV1 SNP rs6466583 interacted with APOL1 in transplants from AA donors. Thus, the T allele at ABCB1 rs1045642 is associated with shorter renal allograft survival for kidneys from American donors. Interactions between ABCB1 and CAV1 with APOL1 may influence allograft failure for transplanted kidneys from AA donors.

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Published In

Kidney Int

DOI

EISSN

1523-1755

Publication Date

September 2015

Volume

88

Issue

3

Start / End Page

584 / 592

Location

United States

Related Subject Headings

  • Young Adult
  • White People
  • Urology & Nephrology
  • United States
  • Treatment Outcome
  • Tissue Donors
  • Time Factors
  • Risk Factors
  • Proportional Hazards Models
  • Polymorphism, Single Nucleotide
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ma, J., Divers, J., Palmer, N. D., Julian, B. A., Israni, A. K., Schladt, D., … Freedman, B. I. (2015). Deceased donor multidrug resistance protein 1 and caveolin 1 gene variants may influence allograft survival in kidney transplantation. Kidney Int, 88(3), 584–592. https://doi.org/10.1038/ki.2015.105
Ma, Jun, Jasmin Divers, Nicholette D. Palmer, Bruce A. Julian, Ajay K. Israni, David Schladt, Stephen O. Pastan, et al. “Deceased donor multidrug resistance protein 1 and caveolin 1 gene variants may influence allograft survival in kidney transplantation.Kidney Int 88, no. 3 (September 2015): 584–92. https://doi.org/10.1038/ki.2015.105.
Ma J, Divers J, Palmer ND, Julian BA, Israni AK, Schladt D, et al. Deceased donor multidrug resistance protein 1 and caveolin 1 gene variants may influence allograft survival in kidney transplantation. Kidney Int. 2015 Sep;88(3):584–92.
Ma, Jun, et al. “Deceased donor multidrug resistance protein 1 and caveolin 1 gene variants may influence allograft survival in kidney transplantation.Kidney Int, vol. 88, no. 3, Sept. 2015, pp. 584–92. Pubmed, doi:10.1038/ki.2015.105.
Ma J, Divers J, Palmer ND, Julian BA, Israni AK, Schladt D, Pastan SO, Chattrabhuti K, Gautreaux MD, Hauptfeld V, Bray RA, Kirk AD, Brown WM, Gaston RS, Rogers J, Farney AC, Orlando G, Stratta RJ, Guan M, Palanisamy A, Reeves-Daniel AM, Bowden DW, Langefeld CD, Hicks PJ, Ma L, Freedman BI. Deceased donor multidrug resistance protein 1 and caveolin 1 gene variants may influence allograft survival in kidney transplantation. Kidney Int. 2015 Sep;88(3):584–592.
Journal cover image

Published In

Kidney Int

DOI

EISSN

1523-1755

Publication Date

September 2015

Volume

88

Issue

3

Start / End Page

584 / 592

Location

United States

Related Subject Headings

  • Young Adult
  • White People
  • Urology & Nephrology
  • United States
  • Treatment Outcome
  • Tissue Donors
  • Time Factors
  • Risk Factors
  • Proportional Hazards Models
  • Polymorphism, Single Nucleotide