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IL-10, IL-15, IL-17, and GMCSF levels in cervical cancer tissue of Tanzanian women infected with HPV16/18 vs. non-HPV16/18 genotypes.

Publication ,  Journal Article
Vidal, AC; Skaar, D; Maguire, R; Dodor, S; Musselwhite, LW; Bartlett, JA; Oneko, O; Obure, J; Mlay, P; Murphy, SK; Hoyo, C
Published in: Infect Agent Cancer
2015

BACKGROUND: Despite comparable screening rates for precancerous lesions, higher incidence and mortality related to cervical cancer in minority women persists. Recent evidence suggests that minority women with precancerous cervical lesions harbor a wider range of human papillomavirus (HPV) genotypes, many of these distinct from HPV16/18, those most commonly found in Caucasian women. The goal of the analysis was to determine if inflammatory cytokines and chemokines varied by HPV 16/18 versus other genotypes in cervical cancer tissues from Tanzanian women. METHODS: HPV genotypes and concentrations of chemokines and cytokines were measured from homogenized fresh tumor tissue of thirty-one women with invasive cervical cancer (ICC). Risk factors for cervical cancer including age, parity, hormonal contraceptive use and cigarette smoking were obtained by questionnaire. Generalized linear models were used to evaluate differences between chemokines/cytokine levels in women infected with HPV16/18 and those infected with other HPV genotypes. RESULTS: After adjusting for age, parity and hormonal contraceptives, IL-17 was found significantly more frequently in invasive cervical cancer samples of women infected with HPV16/18 compared to women infected with other HPV genotypes (p = 0.033). In contrast, higher levels for granular macrophage colony-stimulating factor (p = 0.004), IL-10 (p = 0.037), and IL-15 (p = 0.041) were found in ICC tissues of women infected with genotypes other than HPV16/18 when compared to those of women infected with HPV16/18. CONCLUSIONS: While the small sample size limits inference, our data suggest that infection with different HPV genotypes is associated with distinct pro-inflammatory cytokine expression profiles; whether this explains some of the racial differences observed in cervical cancer is still unclear. Future studies are needed to confirm these findings.

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Published In

Infect Agent Cancer

DOI

ISSN

1750-9378

Publication Date

2015

Volume

10

Start / End Page

10

Location

England

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
  • 1108 Medical Microbiology
 

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Vidal, A. C., Skaar, D., Maguire, R., Dodor, S., Musselwhite, L. W., Bartlett, J. A., … Hoyo, C. (2015). IL-10, IL-15, IL-17, and GMCSF levels in cervical cancer tissue of Tanzanian women infected with HPV16/18 vs. non-HPV16/18 genotypes. Infect Agent Cancer, 10, 10. https://doi.org/10.1186/s13027-015-0005-1
Vidal, Adriana C., David Skaar, Rachel Maguire, Seyram Dodor, Laura W. Musselwhite, John A. Bartlett, Olola Oneko, et al. “IL-10, IL-15, IL-17, and GMCSF levels in cervical cancer tissue of Tanzanian women infected with HPV16/18 vs. non-HPV16/18 genotypes.Infect Agent Cancer 10 (2015): 10. https://doi.org/10.1186/s13027-015-0005-1.
Vidal AC, Skaar D, Maguire R, Dodor S, Musselwhite LW, Bartlett JA, et al. IL-10, IL-15, IL-17, and GMCSF levels in cervical cancer tissue of Tanzanian women infected with HPV16/18 vs. non-HPV16/18 genotypes. Infect Agent Cancer. 2015;10:10.
Vidal, Adriana C., et al. “IL-10, IL-15, IL-17, and GMCSF levels in cervical cancer tissue of Tanzanian women infected with HPV16/18 vs. non-HPV16/18 genotypes.Infect Agent Cancer, vol. 10, 2015, p. 10. Pubmed, doi:10.1186/s13027-015-0005-1.
Vidal AC, Skaar D, Maguire R, Dodor S, Musselwhite LW, Bartlett JA, Oneko O, Obure J, Mlay P, Murphy SK, Hoyo C. IL-10, IL-15, IL-17, and GMCSF levels in cervical cancer tissue of Tanzanian women infected with HPV16/18 vs. non-HPV16/18 genotypes. Infect Agent Cancer. 2015;10:10.
Journal cover image

Published In

Infect Agent Cancer

DOI

ISSN

1750-9378

Publication Date

2015

Volume

10

Start / End Page

10

Location

England

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
  • 1108 Medical Microbiology