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Preliminary clinical evaluation of a 4D-CBCT estimation technique using prior information and limited-angle projections.

Publication ,  Journal Article
Zhang, Y; Yin, F-F; Pan, T; Vergalasova, I; Ren, L
Published in: Radiother Oncol
April 2015

BACKGROUND AND PURPOSE: A technique has been previously reported to estimate high-quality 4D-CBCT using prior information and limited-angle projections. This study is to investigate its clinical feasibility through both phantom and patient studies. MATERIALS AND METHODS: The new technique used to estimate 4D-CBCT is called MMFD-NCC. It is based on the previously reported motion modeling and free-form deformation (MMFD) method, with the introduction of normalized-cross-correlation (NCC) as a new similarity metric. The clinical feasibility of this technique was evaluated by assessing the accuracy of estimated anatomical structures in comparison to those in the 'ground-truth' reference 4D-CBCTs, using data obtained from a physical phantom and three lung cancer patients. Both volume percentage error (VPE) and center-of-mass error (COME) of the estimated tumor volume were used as the evaluation metrics. RESULTS: The average VPE/COME of the tumor in the prior image was 257.1%/10.1 mm for the phantom study and 55.6%/3.8 mm for the patient study. Using only orthogonal-view 30° projections, the MMFD-NCC has reduced the corresponding values to 7.7%/1.2 mm and 9.6%/1.1 mm, respectively. CONCLUSION: The MMFD-NCC technique is able to estimate 4D-CBCT images with geometrical accuracy of the tumor within 10% VPE and 2 mm COME, which can be used to improve the localization accuracy of radiotherapy.

Duke Scholars

Published In

Radiother Oncol

DOI

EISSN

1879-0887

Publication Date

April 2015

Volume

115

Issue

1

Start / End Page

22 / 29

Location

Ireland

Related Subject Headings

  • Phantoms, Imaging
  • Oncology & Carcinogenesis
  • Motion
  • Lung Neoplasms
  • Humans
  • Four-Dimensional Computed Tomography
  • Cone-Beam Computed Tomography
  • 5105 Medical and biological physics
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhang, Y., Yin, F.-F., Pan, T., Vergalasova, I., & Ren, L. (2015). Preliminary clinical evaluation of a 4D-CBCT estimation technique using prior information and limited-angle projections. Radiother Oncol, 115(1), 22–29. https://doi.org/10.1016/j.radonc.2015.02.022
Zhang, You, Fang-Fang Yin, Tinsu Pan, Irina Vergalasova, and Lei Ren. “Preliminary clinical evaluation of a 4D-CBCT estimation technique using prior information and limited-angle projections.Radiother Oncol 115, no. 1 (April 2015): 22–29. https://doi.org/10.1016/j.radonc.2015.02.022.
Zhang Y, Yin F-F, Pan T, Vergalasova I, Ren L. Preliminary clinical evaluation of a 4D-CBCT estimation technique using prior information and limited-angle projections. Radiother Oncol. 2015 Apr;115(1):22–9.
Zhang, You, et al. “Preliminary clinical evaluation of a 4D-CBCT estimation technique using prior information and limited-angle projections.Radiother Oncol, vol. 115, no. 1, Apr. 2015, pp. 22–29. Pubmed, doi:10.1016/j.radonc.2015.02.022.
Zhang Y, Yin F-F, Pan T, Vergalasova I, Ren L. Preliminary clinical evaluation of a 4D-CBCT estimation technique using prior information and limited-angle projections. Radiother Oncol. 2015 Apr;115(1):22–29.
Journal cover image

Published In

Radiother Oncol

DOI

EISSN

1879-0887

Publication Date

April 2015

Volume

115

Issue

1

Start / End Page

22 / 29

Location

Ireland

Related Subject Headings

  • Phantoms, Imaging
  • Oncology & Carcinogenesis
  • Motion
  • Lung Neoplasms
  • Humans
  • Four-Dimensional Computed Tomography
  • Cone-Beam Computed Tomography
  • 5105 Medical and biological physics
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences