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Malignant (Diffuse) Mesothelioma in Patients With Hematologic Malignancies: A Clinicopathologic Study of 45 Cases.

Publication ,  Journal Article
Li, X; Brownlee, NA; Sporn, TA; Mahar, A; Roggli, VL
Published in: Arch Pathol Lab Med
September 2015

CONTEXT: Ionizing radiation has a role in the development of malignant mesothelioma, in several epidemiologic studies, including patients with hematologic malignancies. OBJECTIVE: To study the clinicopathologic characteristics of patients with malignant mesothelioma and hematologic malignancies with and without a history of radiotherapy. DESIGN: From a database of approximately 3600 patients with malignant mesothelioma, we identified 45 patients (1%) who also had hematologic malignancies. We examined clinicopathologic features and noted whether the patient had received radiotherapy for malignancy, comparing those with and those without such exposure. RESULTS: Among the 45 cases, 18 (40%) had Hodgkin lymphoma, 15 (33%) had non-Hodgkin lymphoma, 10 (4%) had chronic lymphocytic leukemia, and 2 (22%) had chronic myelogenous leukemia; 20 patients (44%) had a history of radiotherapy, and 23 (51%) did not. Most patients with Hodgkin lymphoma (16 of 18; 90.0%) received radiation, whereas none of the patients with leukemia (0 of 12) and only 20% (3 of 15) of the patients with non-Hodgkin lymphoma did so. Patients without radiation were older than patients who received radiotherapy (median, 73 versus 54 years, respectively; P < .001), had a shorter interval from diagnosis of hematologic malignancy to that of mesothelioma (median, 2 versus 24 years, respectively; P < .001), and had a shorter survival period (median, 6.0 versus 14.0 months, respectively; P = .02). Epithelial mesotheliomas were proportionately more common in patients with a history of radiotherapy. CONCLUSIONS: Patients with mesothelioma and hematologic malignancies with a history of radiation tended to be younger, had a longer interval from diagnosis of hematologic malignancy to that of mesothelioma, had a longer survival period, and were more likely to have the epithelial variant compared with patients without radiotherapy.

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Published In

Arch Pathol Lab Med

DOI

EISSN

1543-2165

Publication Date

September 2015

Volume

139

Issue

9

Start / End Page

1129 / 1136

Location

United States

Related Subject Headings

  • Young Adult
  • Time Factors
  • Risk Factors
  • Radiotherapy
  • Pathology
  • Neoplasms, Radiation-Induced
  • Neoplasms, Multiple Primary
  • Middle Aged
  • Mesothelioma, Malignant
  • Mesothelioma
 

Citation

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Chicago
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Li, X., Brownlee, N. A., Sporn, T. A., Mahar, A., & Roggli, V. L. (2015). Malignant (Diffuse) Mesothelioma in Patients With Hematologic Malignancies: A Clinicopathologic Study of 45 Cases. Arch Pathol Lab Med, 139(9), 1129–1136. https://doi.org/10.5858/arpa.2014-0569-OA
Li, Xin, Noel A. Brownlee, Thomas A. Sporn, Annabelle Mahar, and Victor L. Roggli. “Malignant (Diffuse) Mesothelioma in Patients With Hematologic Malignancies: A Clinicopathologic Study of 45 Cases.Arch Pathol Lab Med 139, no. 9 (September 2015): 1129–36. https://doi.org/10.5858/arpa.2014-0569-OA.
Li X, Brownlee NA, Sporn TA, Mahar A, Roggli VL. Malignant (Diffuse) Mesothelioma in Patients With Hematologic Malignancies: A Clinicopathologic Study of 45 Cases. Arch Pathol Lab Med. 2015 Sep;139(9):1129–36.
Li, Xin, et al. “Malignant (Diffuse) Mesothelioma in Patients With Hematologic Malignancies: A Clinicopathologic Study of 45 Cases.Arch Pathol Lab Med, vol. 139, no. 9, Sept. 2015, pp. 1129–36. Pubmed, doi:10.5858/arpa.2014-0569-OA.
Li X, Brownlee NA, Sporn TA, Mahar A, Roggli VL. Malignant (Diffuse) Mesothelioma in Patients With Hematologic Malignancies: A Clinicopathologic Study of 45 Cases. Arch Pathol Lab Med. 2015 Sep;139(9):1129–1136.

Published In

Arch Pathol Lab Med

DOI

EISSN

1543-2165

Publication Date

September 2015

Volume

139

Issue

9

Start / End Page

1129 / 1136

Location

United States

Related Subject Headings

  • Young Adult
  • Time Factors
  • Risk Factors
  • Radiotherapy
  • Pathology
  • Neoplasms, Radiation-Induced
  • Neoplasms, Multiple Primary
  • Middle Aged
  • Mesothelioma, Malignant
  • Mesothelioma