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An efficient calculation method for pharmacokinetic parameters in brain permeability study using dynamic contrast-enhanced MRI.

Publication ,  Journal Article
Wang, C; Yin, F-F; Chang, Z
Published in: Magn Reson Med
February 2016

PURPOSE: To develop an efficient method for calculating pharmacokinetic (PK) parameters in brain DCE-MRI permeability studies. METHODS: A linear least-squares fitting algorithm based on a derivative expression of the two-compartment PK model was proposed to analytically solve for the PK parameters. Noise in the expression was minimized through low-pass filtering. Simulation studies were conducted in which the proposed method was compared with two existing methods in terms of accuracy and efficiency. Five in vivo brain studies were demonstrated for potential clinical application. RESULTS: In the simulation studies using chosen parameter values, the calculated percent difference of K(trans) by the proposed method was <5.0% with a temporal resolution (Δt) < 5 s, and the accuracies of all parameter results were better or comparable to existing methods. When analyzed within certain parameter intensity ranges, the proposed method was more accurate than the existing methods and improved the efficiency by a factor of up to 458 for a Δt = 1 s and up to 38 for a Δt = 5 s. In the in vivo study, the calculated parameters using the proposed method were comparable to those using the existing methods with improved efficiencies. CONCLUSIONS: An efficient method was developed for the accurate and efficient calculation of parameters in brain DCE-MRI permeability studies.

Duke Scholars

Published In

Magn Reson Med

DOI

EISSN

1522-2594

Publication Date

February 2016

Volume

75

Issue

2

Start / End Page

739 / 749

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Imaging
  • Image Processing, Computer-Assisted
  • Humans
  • Contrast Media
  • Computer Simulation
  • Brain
  • Algorithms
  • 4003 Biomedical engineering
  • 0903 Biomedical Engineering
 

Citation

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Wang, C., Yin, F.-F., & Chang, Z. (2016). An efficient calculation method for pharmacokinetic parameters in brain permeability study using dynamic contrast-enhanced MRI. Magn Reson Med, 75(2), 739–749. https://doi.org/10.1002/mrm.25659
Wang, Chunhao, Fang-Fang Yin, and Zheng Chang. “An efficient calculation method for pharmacokinetic parameters in brain permeability study using dynamic contrast-enhanced MRI.Magn Reson Med 75, no. 2 (February 2016): 739–49. https://doi.org/10.1002/mrm.25659.
Wang, Chunhao, et al. “An efficient calculation method for pharmacokinetic parameters in brain permeability study using dynamic contrast-enhanced MRI.Magn Reson Med, vol. 75, no. 2, Feb. 2016, pp. 739–49. Pubmed, doi:10.1002/mrm.25659.
Journal cover image

Published In

Magn Reson Med

DOI

EISSN

1522-2594

Publication Date

February 2016

Volume

75

Issue

2

Start / End Page

739 / 749

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Imaging
  • Image Processing, Computer-Assisted
  • Humans
  • Contrast Media
  • Computer Simulation
  • Brain
  • Algorithms
  • 4003 Biomedical engineering
  • 0903 Biomedical Engineering