P2Y12 receptor inhibitors for secondary prevention of ischemic stroke.
INTRODUCTION: Ischemic stroke (IS) is a major cause of death and disability worldwide. The P2Y12 receptor plays a critical role in the formation of a stable thrombus leading to ischemic complications. Therefore, P2Y12 receptor inhibitors constitute a major antiplatelet strategy in the secondary prevention of IS. AREAS COVERED: We searched articles about P2Y12 receptor inhibitors and stroke in PubMed published until December 2014. This is a comprehensive review of the role of P2Y12 receptor inhibitors alone and in combination with aspirin in the secondary prevention of noncardioembolic stroke. EXPERT OPINION: The potential benefit of more potent antiplatelet therapy for secondary stroke prevention must be weighed against the risk of bleeding in patients with IS. Short-term (≤ 3 months) dual antiplatelet therapy with clopidogrel and aspirin that is initiated early after IS or transient ischemic attack due to large artery atherosclerosis appears most efficient.
Duke Scholars
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Related Subject Headings
- Ticlopidine
- Stroke
- Secondary Prevention
- Receptors, Purinergic P2Y12
- Purinergic P2Y Receptor Antagonists
- Platelet Aggregation Inhibitors
- Pharmacology & Pharmacy
- Ischemic Attack, Transient
- Humans
- Hemorrhage
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Ticlopidine
- Stroke
- Secondary Prevention
- Receptors, Purinergic P2Y12
- Purinergic P2Y Receptor Antagonists
- Platelet Aggregation Inhibitors
- Pharmacology & Pharmacy
- Ischemic Attack, Transient
- Humans
- Hemorrhage