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Antifungal activities of SCY-078 (MK-3118) and standard antifungal agents against clinical non-Aspergillus mold isolates.

Publication ,  Journal Article
Lamoth, F; Alexander, BD
Published in: Antimicrob Agents Chemother
July 2015

The limited armamentarium of active and oral antifungal drugs against emerging non-Aspergillus molds is of particular concern. Current antifungal agents and the new orally available beta-1,3-d-glucan synthase inhibitor SCY-078 were tested in vitro against 135 clinical non-Aspergillus mold isolates. Akin to echinocandins, SCY-078 showed no or poor activity against Mucoromycotina and Fusarium spp. However, SCY-078 was highly active against Paecilomyces variotii and was the only compound displaying some activity against notoriously panresistant Scedosporium prolificans.

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Published In

Antimicrob Agents Chemother

DOI

EISSN

1098-6596

Publication Date

July 2015

Volume

59

Issue

7

Start / End Page

4308 / 4311

Location

United States

Related Subject Headings

  • Triterpenes
  • Retrospective Studies
  • Mycoses
  • Microbiology
  • Microbial Sensitivity Tests
  • Humans
  • Glycosides
  • Glucosyltransferases
  • Fungi
  • Echinocandins
 

Citation

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Lamoth, F., & Alexander, B. D. (2015). Antifungal activities of SCY-078 (MK-3118) and standard antifungal agents against clinical non-Aspergillus mold isolates. Antimicrob Agents Chemother, 59(7), 4308–4311. https://doi.org/10.1128/AAC.00234-15
Lamoth, Frédéric, and Barbara D. Alexander. “Antifungal activities of SCY-078 (MK-3118) and standard antifungal agents against clinical non-Aspergillus mold isolates.Antimicrob Agents Chemother 59, no. 7 (July 2015): 4308–11. https://doi.org/10.1128/AAC.00234-15.
Lamoth, Frédéric, and Barbara D. Alexander. “Antifungal activities of SCY-078 (MK-3118) and standard antifungal agents against clinical non-Aspergillus mold isolates.Antimicrob Agents Chemother, vol. 59, no. 7, July 2015, pp. 4308–11. Pubmed, doi:10.1128/AAC.00234-15.
Lamoth F, Alexander BD. Antifungal activities of SCY-078 (MK-3118) and standard antifungal agents against clinical non-Aspergillus mold isolates. Antimicrob Agents Chemother. 2015 Jul;59(7):4308–4311.

Published In

Antimicrob Agents Chemother

DOI

EISSN

1098-6596

Publication Date

July 2015

Volume

59

Issue

7

Start / End Page

4308 / 4311

Location

United States

Related Subject Headings

  • Triterpenes
  • Retrospective Studies
  • Mycoses
  • Microbiology
  • Microbial Sensitivity Tests
  • Humans
  • Glycosides
  • Glucosyltransferases
  • Fungi
  • Echinocandins