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Surgery results in exaggerated and persistent cognitive decline in a rat model of the Metabolic Syndrome.

Publication ,  Journal Article
Feng, X; Degos, V; Koch, LG; Britton, SL; Zhu, Y; Vacas, S; Terrando, N; Nelson, J; Su, X; Maze, M
Published in: Anesthesiology
May 2013

BACKGROUND: Postoperative cognitive decline can be reproduced in animal models. In a well-validated rat model of the Metabolic Syndrome, we sought to investigate whether surgery induced a more severe and persistent form of cognitive decline similar to that noted in preliminary clinical studies. METHODS: In rats that had been selectively bred for low and high exercise endurance, the low capacity runners (LCR) exhibited features of Metabolic Syndrome (obesity, dyslipidemia, insulin resistance, and hypertension). Tibial fracture surgery was performed under isoflurane anesthesia in LCR and high capacity runner (HCR) rats and cognitive function was assessed postoperatively in a trace-fear conditioning paradigm and Morris Water Maze; non-operated rats were exposed to anesthesia and analgesia (sham). Group sizes were n = 6. RESULTS: On postoperative D7, LCR rats had shorter freezing times than postoperative HCR rats. Five months postoperatively, LCR rats had a flatter learning trajectory and took longer to locate the submerged platform than postoperative HCR rats; dwell-time in the target quadrant in a probe trial was shorter in the postoperative LCR compared to HCR rats. LCR and HCR sham rats did not differ in any test. CONCLUSION: Postoperatively, LCR rats diverged from HCR rats exhibiting a greater decline in memory, acutely, with persistent learning and memory decline, remotely; this could not be attributed to changes in locomotor or swimming performance. This Metabolic Syndrome animal model of surgery-induced cognitive decline corroborates, with high fidelity, preliminary findings of postoperative cognitive dysfunction in Metabolic Syndrome patients.

Duke Scholars

Published In

Anesthesiology

DOI

EISSN

1528-1175

Publication Date

May 2013

Volume

118

Issue

5

Start / End Page

1098 / 1105

Location

United States

Related Subject Headings

  • Tibial Fractures
  • Swimming
  • Space Perception
  • Running
  • Rats
  • Postoperative Complications
  • Motor Activity
  • Metabolic Syndrome
  • Memory, Long-Term
  • Maze Learning
 

Citation

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ICMJE
MLA
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Feng, X., Degos, V., Koch, L. G., Britton, S. L., Zhu, Y., Vacas, S., … Maze, M. (2013). Surgery results in exaggerated and persistent cognitive decline in a rat model of the Metabolic Syndrome. Anesthesiology, 118(5), 1098–1105. https://doi.org/10.1097/ALN.0b013e318286d0c9
Feng, Xiaomei, Vincent Degos, Lauren G. Koch, Steven L. Britton, Yinggang Zhu, Susana Vacas, Niccolò Terrando, Jeffrey Nelson, Xiao Su, and Mervyn Maze. “Surgery results in exaggerated and persistent cognitive decline in a rat model of the Metabolic Syndrome.Anesthesiology 118, no. 5 (May 2013): 1098–1105. https://doi.org/10.1097/ALN.0b013e318286d0c9.
Feng X, Degos V, Koch LG, Britton SL, Zhu Y, Vacas S, et al. Surgery results in exaggerated and persistent cognitive decline in a rat model of the Metabolic Syndrome. Anesthesiology. 2013 May;118(5):1098–105.
Feng, Xiaomei, et al. “Surgery results in exaggerated and persistent cognitive decline in a rat model of the Metabolic Syndrome.Anesthesiology, vol. 118, no. 5, May 2013, pp. 1098–105. Pubmed, doi:10.1097/ALN.0b013e318286d0c9.
Feng X, Degos V, Koch LG, Britton SL, Zhu Y, Vacas S, Terrando N, Nelson J, Su X, Maze M. Surgery results in exaggerated and persistent cognitive decline in a rat model of the Metabolic Syndrome. Anesthesiology. 2013 May;118(5):1098–1105.

Published In

Anesthesiology

DOI

EISSN

1528-1175

Publication Date

May 2013

Volume

118

Issue

5

Start / End Page

1098 / 1105

Location

United States

Related Subject Headings

  • Tibial Fractures
  • Swimming
  • Space Perception
  • Running
  • Rats
  • Postoperative Complications
  • Motor Activity
  • Metabolic Syndrome
  • Memory, Long-Term
  • Maze Learning