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SLCO1B1 genetic variants, long-term low-density lipoprotein cholesterol levels and clinical events in patients following cardiac catheterization.

Publication ,  Journal Article
Li, JH; Suchindran, S; Shah, SH; Kraus, WE; Ginsburg, GS; Voora, D
Published in: Pharmacogenomics
2015

AIM: SLCO1B1 variants are associated with intermediate outcomes that may increase risk of death/myocardial infarction (MI) in statin-treated patients. PATIENTS & METHODS: In high-risk Caucasians undergoing cardiac catheterization, we tested the association between rs4149056/625T>C and rs2306283/492A>G with low-density lipoprotein cholesterol (LDL-c) over 3 years (n = 1402) and death/MI over 6 years (n = 2994), accounting for statin use or type during follow-up. RESULTS: Carriers of the rs4149056 C allele had 6.2 ± 1.7 mg/dl higher LDL-c per C allele (p < 0.001) but were not at higher risk for death/MI (p = 0.9). We found no associations between rs2306283 and LDL-c or death/MI (p > 0.6). CONCLUSION: Functional SLCO1B1 variants are not associated with death/MI in patients commonly treated with statins, despite higher LDL-c in carriers of the rs4149056 C allele.

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Published In

Pharmacogenomics

DOI

EISSN

1744-8042

Publication Date

2015

Volume

16

Issue

5

Start / End Page

449 / 458

Location

England

Related Subject Headings

  • Treatment Outcome
  • Survival Analysis
  • Registries
  • Pharmacology & Pharmacy
  • Organic Anion Transporters
  • Myocardial Infarction
  • Middle Aged
  • Male
  • Liver-Specific Organic Anion Transporter 1
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
 

Citation

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Li, J. H., Suchindran, S., Shah, S. H., Kraus, W. E., Ginsburg, G. S., & Voora, D. (2015). SLCO1B1 genetic variants, long-term low-density lipoprotein cholesterol levels and clinical events in patients following cardiac catheterization. Pharmacogenomics, 16(5), 449–458. https://doi.org/10.2217/pgs.15.2
Li, Josephine H., Sunil Suchindran, Svati H. Shah, William E. Kraus, Geoffrey S. Ginsburg, and Deepak Voora. “SLCO1B1 genetic variants, long-term low-density lipoprotein cholesterol levels and clinical events in patients following cardiac catheterization.Pharmacogenomics 16, no. 5 (2015): 449–58. https://doi.org/10.2217/pgs.15.2.
Li JH, Suchindran S, Shah SH, Kraus WE, Ginsburg GS, Voora D. SLCO1B1 genetic variants, long-term low-density lipoprotein cholesterol levels and clinical events in patients following cardiac catheterization. Pharmacogenomics. 2015;16(5):449–58.
Li, Josephine H., et al. “SLCO1B1 genetic variants, long-term low-density lipoprotein cholesterol levels and clinical events in patients following cardiac catheterization.Pharmacogenomics, vol. 16, no. 5, 2015, pp. 449–58. Pubmed, doi:10.2217/pgs.15.2.
Li JH, Suchindran S, Shah SH, Kraus WE, Ginsburg GS, Voora D. SLCO1B1 genetic variants, long-term low-density lipoprotein cholesterol levels and clinical events in patients following cardiac catheterization. Pharmacogenomics. 2015;16(5):449–458.
Journal cover image

Published In

Pharmacogenomics

DOI

EISSN

1744-8042

Publication Date

2015

Volume

16

Issue

5

Start / End Page

449 / 458

Location

England

Related Subject Headings

  • Treatment Outcome
  • Survival Analysis
  • Registries
  • Pharmacology & Pharmacy
  • Organic Anion Transporters
  • Myocardial Infarction
  • Middle Aged
  • Male
  • Liver-Specific Organic Anion Transporter 1
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors