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Diagnosis of liver fibrosis: present and future.

Publication ,  Journal Article
Patel, K; Bedossa, P; Castera, L
Published in: Semin Liver Dis
May 2015

The diagnostic assessment of liver fibrosis, a major determinant of disease severity, is an important step in the management of patients with chronic liver diseases. Liver biopsy is still considered the gold standard for the assessment of necroinflammation and fibrosis; however, recent technical advances have resulted in the development of numerous serum biomarkers and imaging tools as noninvasive alternatives to biopsy. These tests include biological (serum biomarker algorithms), physical (imaging assessment of tissue stiffness), and physiological (breath test) methods. Accumulating evidence shows that noninvasive tests provide prognostic information of clinical relevance, which has led to their incorporation into clinical guidelines and everyday practice. Here, the authors review and compare invasive and noninvasive tests for the diagnosis of liver fibrosis. They discuss emerging functional genomic, microparticle, protein-profiling, and bioimaging tools, focusing on novel sensitive tools that are able to assess the dynamic nature of fibrogenesis, a key requirement for the assessment of the efficacy of antifibrotic compounds in the future.

Duke Scholars

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Published In

Semin Liver Dis

DOI

EISSN

1098-8971

Publication Date

May 2015

Volume

35

Issue

2

Start / End Page

166 / 183

Location

United States

Related Subject Headings

  • Liver Cirrhosis
  • Liver
  • Humans
  • Gastroenterology & Hepatology
  • Diagnostic Imaging
  • Biopsy
  • Biomarkers
  • Algorithms
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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Patel, K., Bedossa, P., & Castera, L. (2015). Diagnosis of liver fibrosis: present and future. Semin Liver Dis, 35(2), 166–183. https://doi.org/10.1055/s-0035-1550059
Patel, Keyur, Pierre Bedossa, and Laurent Castera. “Diagnosis of liver fibrosis: present and future.Semin Liver Dis 35, no. 2 (May 2015): 166–83. https://doi.org/10.1055/s-0035-1550059.
Patel K, Bedossa P, Castera L. Diagnosis of liver fibrosis: present and future. Semin Liver Dis. 2015 May;35(2):166–83.
Patel, Keyur, et al. “Diagnosis of liver fibrosis: present and future.Semin Liver Dis, vol. 35, no. 2, May 2015, pp. 166–83. Pubmed, doi:10.1055/s-0035-1550059.
Patel K, Bedossa P, Castera L. Diagnosis of liver fibrosis: present and future. Semin Liver Dis. 2015 May;35(2):166–183.
Journal cover image

Published In

Semin Liver Dis

DOI

EISSN

1098-8971

Publication Date

May 2015

Volume

35

Issue

2

Start / End Page

166 / 183

Location

United States

Related Subject Headings

  • Liver Cirrhosis
  • Liver
  • Humans
  • Gastroenterology & Hepatology
  • Diagnostic Imaging
  • Biopsy
  • Biomarkers
  • Algorithms
  • 3202 Clinical sciences
  • 1103 Clinical Sciences