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TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation.

Publication ,  Journal Article
Ci, X; Kuraoka, M; Wang, H; Carico, Z; Hopper, K; Shin, J; Deng, X; Qiu, Y; Unniraman, S; Kelsoe, G; Zhong, X-P
Published in: PLoS One
2015

Accumulating evidence indicates that the tuberous sclerosis complex 1 (TSC1), a tumor suppressor that acts by inhibiting mTOR signaling, plays an important role in the immune system. We report here that TSC1 differentially regulates mTOR complex 1 (mTORC1) and mTORC2/Akt signaling in B cells. TSC1 deficiency results in the accumulation of transitional-1 (T1) B cells and progressive losses of B cells as they mature beyond the T1 stage. Moreover, TSC1KO mice exhibit a mild defect in the serum antibody responses or rate of Ig class-switch recombination after immunization with a T-cell-dependent antigen. In contrast to a previous report, we demonstrate that both constitutive Peyer's patch germinal centers (GCs) and immunization-induced splenic GCs are unimpaired in TSC1-deficient (TSC1KO) mice and that the ratio of GC B cells to total B cells is comparable in WT and TSC1KO mice. Together, our data demonstrate that TSC1 plays important roles for B cell development, but it is dispensable for GC formation and serum antibody responses.

Duke Scholars

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Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2015

Volume

10

Issue

5

Start / End Page

e0127527

Location

United States

Related Subject Headings

  • Tumor Suppressor Proteins
  • Tuberous Sclerosis Complex 1 Protein
  • TOR Serine-Threonine Kinases
  • Spleen
  • Signal Transduction
  • Proto-Oncogene Proteins c-akt
  • Peyer's Patches
  • Multiprotein Complexes
  • Mice, Knockout
  • Mice
 

Citation

APA
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MLA
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Ci, X., Kuraoka, M., Wang, H., Carico, Z., Hopper, K., Shin, J., … Zhong, X.-P. (2015). TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation. PLoS One, 10(5), e0127527. https://doi.org/10.1371/journal.pone.0127527
Ci, Xinxin, Masayuki Kuraoka, Hongxia Wang, Zachary Carico, Kristen Hopper, Jinwook Shin, Xuming Deng, et al. “TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation.PLoS One 10, no. 5 (2015): e0127527. https://doi.org/10.1371/journal.pone.0127527.
Ci X, Kuraoka M, Wang H, Carico Z, Hopper K, Shin J, et al. TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation. PLoS One. 2015;10(5):e0127527.
Ci, Xinxin, et al. “TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation.PLoS One, vol. 10, no. 5, 2015, p. e0127527. Pubmed, doi:10.1371/journal.pone.0127527.
Ci X, Kuraoka M, Wang H, Carico Z, Hopper K, Shin J, Deng X, Qiu Y, Unniraman S, Kelsoe G, Zhong X-P. TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation. PLoS One. 2015;10(5):e0127527.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2015

Volume

10

Issue

5

Start / End Page

e0127527

Location

United States

Related Subject Headings

  • Tumor Suppressor Proteins
  • Tuberous Sclerosis Complex 1 Protein
  • TOR Serine-Threonine Kinases
  • Spleen
  • Signal Transduction
  • Proto-Oncogene Proteins c-akt
  • Peyer's Patches
  • Multiprotein Complexes
  • Mice, Knockout
  • Mice