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Chemotherapy-related amenorrhea after adjuvant paclitaxel-trastuzumab (APT trial).

Publication ,  Journal Article
Ruddy, KJ; Guo, H; Barry, W; Dang, CT; Yardley, DA; Moy, B; Marcom, PK; Albain, KS; Rugo, HS; Ellis, MJ; Shapira, I; Wolff, AC; Carey, LA ...
Published in: Breast Cancer Res Treat
June 2015

Chemotherapy-related amenorrhea (CRA) is associated with infertility and menopausal symptoms. Learning how frequently paclitaxel and trastuzumab cause amenorrhea is important. Most other adjuvant breast cancer therapies induce CRA in approximately 50 % of all premenopausal recipients [1]. 410 patients enrolled on the APT Trial, a single-arm phase 2 adjuvant study of 12 weeks of paclitaxel and trastuzumab followed by nine months of trastuzumab monotherapy. Eligible patients had ≤3 cm node-negative HER2 + breast cancers. Premenopausal enrollees were asked to complete menstrual surveys every 3-12 months for 72 months. Women who responded to at least one survey at least 15 months after chemotherapy initiation (and who did not undergo hysterectomy and/or bilateral oophorectomy or receive ovarian suppressing medications prior to 15 months) were included in this analysis. A participant was defined as having amenorrhea in follow-up if her self-reported last menstrual period at last follow-up was greater than 12 months prior to the survey. Among the 64 women in the evaluable population (median age at study entry 44 years, range 27-52 years), the median time between chemotherapy initiation and last menstrual survey was 51 months (range 16-79). 18 of 64 women (28 %, 95 % CI 18-41 %) were amenorrheic at that time point. Amenorrhea rates among premenopausal women treated with adjuvant paclitaxel and trastuzumab for early stage breast cancer appear lower than those seen historically with standard alkylator-based breast cancer regimens. Future studies are needed to understand the impact of this regimen on related issues of fertility and menopausal symptoms.

Duke Scholars

Published In

Breast Cancer Res Treat

DOI

EISSN

1573-7217

Publication Date

June 2015

Volume

151

Issue

3

Start / End Page

589 / 596

Location

Netherlands

Related Subject Headings

  • Tumor Burden
  • Trastuzumab
  • Paclitaxel
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Neoplasm Grading
  • Middle Aged
  • Humans
  • Follow-Up Studies
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ruddy, K. J., Guo, H., Barry, W., Dang, C. T., Yardley, D. A., Moy, B., … Tolaney, S. M. (2015). Chemotherapy-related amenorrhea after adjuvant paclitaxel-trastuzumab (APT trial). Breast Cancer Res Treat, 151(3), 589–596. https://doi.org/10.1007/s10549-015-3426-z
Ruddy, Kathryn J., Hao Guo, William Barry, Chau T. Dang, Denise A. Yardley, Beverly Moy, P Kelly Marcom, et al. “Chemotherapy-related amenorrhea after adjuvant paclitaxel-trastuzumab (APT trial).Breast Cancer Res Treat 151, no. 3 (June 2015): 589–96. https://doi.org/10.1007/s10549-015-3426-z.
Ruddy KJ, Guo H, Barry W, Dang CT, Yardley DA, Moy B, et al. Chemotherapy-related amenorrhea after adjuvant paclitaxel-trastuzumab (APT trial). Breast Cancer Res Treat. 2015 Jun;151(3):589–96.
Ruddy, Kathryn J., et al. “Chemotherapy-related amenorrhea after adjuvant paclitaxel-trastuzumab (APT trial).Breast Cancer Res Treat, vol. 151, no. 3, June 2015, pp. 589–96. Pubmed, doi:10.1007/s10549-015-3426-z.
Ruddy KJ, Guo H, Barry W, Dang CT, Yardley DA, Moy B, Marcom PK, Albain KS, Rugo HS, Ellis MJ, Shapira I, Wolff AC, Carey LA, Overmoyer BA, Hudis C, Krop IE, Burstein HJ, Winer EP, Partridge AH, Tolaney SM. Chemotherapy-related amenorrhea after adjuvant paclitaxel-trastuzumab (APT trial). Breast Cancer Res Treat. 2015 Jun;151(3):589–596.
Journal cover image

Published In

Breast Cancer Res Treat

DOI

EISSN

1573-7217

Publication Date

June 2015

Volume

151

Issue

3

Start / End Page

589 / 596

Location

Netherlands

Related Subject Headings

  • Tumor Burden
  • Trastuzumab
  • Paclitaxel
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Neoplasm Grading
  • Middle Aged
  • Humans
  • Follow-Up Studies
  • Female