Human olfactory receptor responses to odorants.
Publication
, Journal Article
Mainland, JD; Li, YR; Zhou, T; Liu, WLL; Matsunami, H
Published in: Sci Data
2015
Although the human olfactory system is capable of discriminating a vast number of odors, we do not currently understand what chemical features are encoded by olfactory receptors. In large part this is due to a paucity of data in a search space covering the interactions of hundreds of receptors with billions of odorous molecules. Of the approximately 400 intact human odorant receptors, only 10% have a published ligand. Here we used a heterologous luciferase assay to screen 73 odorants against a clone library of 511 human olfactory receptors. This dataset will allow other researchers to interrogate the combinatorial nature of olfactory coding.
Duke Scholars
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Published In
Sci Data
DOI
ISSN
2052-4463
Publication Date
2015
Volume
2
Start / End Page
150002
Location
England
Related Subject Headings
- Receptors, Odorant
- Odorants
- Luciferases
- Ligands
- Humans
- Biological Assay
Citation
APA
Chicago
ICMJE
MLA
NLM
Mainland, J. D., Li, Y. R., Zhou, T., Liu, W. L. L., & Matsunami, H. (2015). Human olfactory receptor responses to odorants. Sci Data, 2, 150002. https://doi.org/10.1038/sdata.2015.2
Mainland, Joel D., Yun R. Li, Ting Zhou, Wen Ling L. Liu, and Hiroaki Matsunami. “Human olfactory receptor responses to odorants.” Sci Data 2 (2015): 150002. https://doi.org/10.1038/sdata.2015.2.
Mainland JD, Li YR, Zhou T, Liu WLL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015;2:150002.
Mainland, Joel D., et al. “Human olfactory receptor responses to odorants.” Sci Data, vol. 2, 2015, p. 150002. Pubmed, doi:10.1038/sdata.2015.2.
Mainland JD, Li YR, Zhou T, Liu WLL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015;2:150002.
Published In
Sci Data
DOI
ISSN
2052-4463
Publication Date
2015
Volume
2
Start / End Page
150002
Location
England
Related Subject Headings
- Receptors, Odorant
- Odorants
- Luciferases
- Ligands
- Humans
- Biological Assay