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Circulating Tumor Cells in Biochemical Recurrence of Prostate Cancer.

Publication ,  Journal Article
Aragon-Ching, JB; Siegel, RS; Frazier, H; Andrawis, R; Hendricks, F; Phillips, M; Jarrett, T; Guebre-Xabiher, H; Patierno, S; Simmens, SJ
Published in: Clin Genitourin Cancer
October 2015

OBJECTIVE: Circulating tumor cells (CTCs) have known prognostic implications in metastatic castration-resistant prostate cancer, but little is known regarding its utility in biochemical recurrence (BR) of prostate cancer. The primary objectives were to determine whether CTCs are measurable in patients with BR and whether it can reliably predict prostate-specific antigen (PSA) increase and PSA doubling times (PSADTs). METHODS: BR was identified in patients after prostatectomy or radiation or both, with a PSA increase of ≥ 0.2 for prior prostatectomy or > 2 mg/dL increase for post-nadir in prior radiotherapy. CTCs were enumerated at baseline at the time of study entry using the CellSearch (Janssen Diagnostics, Raritan, NJ) test. RESULTS: The median age for all 36 patients accrued was 69.5 years (range, 51-91) with a median PSA of 1.65 ng/mL (range, 0.2-65.8). Gleason scores ranged from 5 to 9 (median, 7). The majority had prostatectomy (n = 25), external beam radiotherapy (n = 9), CyberKnife (Accuray, Sunnyvale, CA) (n = 1), and combined radiohormonal therapy (n = 1). PSADT ranged from 0.35 to 55 months, with a median of 7.43 months. The incidence of positive CTCs was 8.3% (3 patients), of whom 2 had biopsy-proven bony lesions on presenting with equivocal scans and PSADTs of 2.27 and 3.08 months, respectively. The third CTC-positive patient had a PSADT of 4.99 months. CONCLUSIONS: Obtaining CTCs in unselected patients presenting with BR has a relatively low yield. However, obtaining a positive CTC raises the suspicion of the presence of metastatic disease and may have utility for longitudinal follow-ups of patients with BR.

Duke Scholars

Published In

Clin Genitourin Cancer

DOI

EISSN

1938-0682

Publication Date

October 2015

Volume

13

Issue

5

Start / End Page

e341 / e345

Location

United States

Related Subject Headings

  • Prostatic Neoplasms
  • Prostate-Specific Antigen
  • Prognosis
  • Oncology & Carcinogenesis
  • Neoplastic Cells, Circulating
  • Neoplasm Metastasis
  • Neoplasm Grading
  • Middle Aged
  • Male
  • Humans
 

Citation

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ICMJE
MLA
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Aragon-Ching, J. B., Siegel, R. S., Frazier, H., Andrawis, R., Hendricks, F., Phillips, M., … Simmens, S. J. (2015). Circulating Tumor Cells in Biochemical Recurrence of Prostate Cancer. Clin Genitourin Cancer, 13(5), e341–e345. https://doi.org/10.1016/j.clgc.2015.04.003
Aragon-Ching, Jeanny B., Robert S. Siegel, Harold Frazier, Ramez Andrawis, Frederick Hendricks, Michael Phillips, Thomas Jarrett, Hiwot Guebre-Xabiher, Steven Patierno, and Samuel J. Simmens. “Circulating Tumor Cells in Biochemical Recurrence of Prostate Cancer.Clin Genitourin Cancer 13, no. 5 (October 2015): e341–45. https://doi.org/10.1016/j.clgc.2015.04.003.
Aragon-Ching JB, Siegel RS, Frazier H, Andrawis R, Hendricks F, Phillips M, et al. Circulating Tumor Cells in Biochemical Recurrence of Prostate Cancer. Clin Genitourin Cancer. 2015 Oct;13(5):e341–5.
Aragon-Ching, Jeanny B., et al. “Circulating Tumor Cells in Biochemical Recurrence of Prostate Cancer.Clin Genitourin Cancer, vol. 13, no. 5, Oct. 2015, pp. e341–45. Pubmed, doi:10.1016/j.clgc.2015.04.003.
Aragon-Ching JB, Siegel RS, Frazier H, Andrawis R, Hendricks F, Phillips M, Jarrett T, Guebre-Xabiher H, Patierno S, Simmens SJ. Circulating Tumor Cells in Biochemical Recurrence of Prostate Cancer. Clin Genitourin Cancer. 2015 Oct;13(5):e341–e345.
Journal cover image

Published In

Clin Genitourin Cancer

DOI

EISSN

1938-0682

Publication Date

October 2015

Volume

13

Issue

5

Start / End Page

e341 / e345

Location

United States

Related Subject Headings

  • Prostatic Neoplasms
  • Prostate-Specific Antigen
  • Prognosis
  • Oncology & Carcinogenesis
  • Neoplastic Cells, Circulating
  • Neoplasm Metastasis
  • Neoplasm Grading
  • Middle Aged
  • Male
  • Humans