Avascular necrosis in pediatric systemic lupus erythematosus: a brief report and review of the literature.
UNLABELLED: Avascular necrosis (AVN) occurs in several chronic illnesses, including systemic lupus erythematosus (SLE), but can also occur in healthy children. There are multiple theories to explain why and how AVN occurs, but an exact mechanism has yet to be unraveled. AVN in the pediatric lupus population is understudied. The Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) trial, provides an excellent venue to conduct an exploratory analysis to assess associations between AVN and demographics, SLE disease activity and vitamin D deficiency. Herein we present a brief report describing our findings, as well as reviewing the literature on AVN in SLE and other entities. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT00065806.
Duke Scholars
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Related Subject Headings
- Vitamin D Deficiency
- Vasodilator Agents
- Severity of Illness Index
- Osteonecrosis
- Orthopedics
- Lupus Erythematosus, Systemic
- Humans
- Diphosphonates
- Child
- Cell- and Tissue-Based Therapy
Citation
Published In
DOI
EISSN
Publication Date
Volume
Start / End Page
Location
Related Subject Headings
- Vitamin D Deficiency
- Vasodilator Agents
- Severity of Illness Index
- Osteonecrosis
- Orthopedics
- Lupus Erythematosus, Systemic
- Humans
- Diphosphonates
- Child
- Cell- and Tissue-Based Therapy