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Sickle cell disease is associated with iron mediated hypercoagulability.

Publication ,  Journal Article
Shah, N; Welsby, IJ; Fielder, MA; Jacobsen, WK; Nielsen, VG
Published in: J Thromb Thrombolysis
August 2015

Sickle cell disease (SCD) is associated with a significant hypercoagulable state and several hemostatic anomalies have been identified in this disease state. Of interest, SCD patients can become iron overloaded after transfusion, and iron can enhance fibrinogen as a substrate for thrombin, resulting in thrombi that commence coagulation quickly and form rapidly. We hypothesized that SCD patients would display hypercoagulable plasma coagulation kinetics and an iron enhancement of coagulation. After obtaining IRB approval, we assessed coagulation kinetics and iron enhancement with viscoelastic methods in archived, citrated plasma obtained from ambulatory or hospitalized SCD patients (n = 20). All SCD patients had plasmatic hypercoagulability, and 65 % were positive for iron enhancement of coagulation. In conclusion, continuing investigation correlating such viscoelastic data with clinical symptoms may provide insight into the role played by iron in the setting of SCD, including complications such as vaso-occlusive crisis.

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Published In

J Thromb Thrombolysis

DOI

EISSN

1573-742X

Publication Date

August 2015

Volume

40

Issue

2

Start / End Page

182 / 185

Location

Netherlands

Related Subject Headings

  • Thrombophilia
  • Male
  • Iron Overload
  • Iron
  • Humans
  • Female
  • Child, Preschool
  • Child
  • Cardiovascular System & Hematology
  • Blood Coagulation
 

Citation

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Shah, N., Welsby, I. J., Fielder, M. A., Jacobsen, W. K., & Nielsen, V. G. (2015). Sickle cell disease is associated with iron mediated hypercoagulability. J Thromb Thrombolysis, 40(2), 182–185. https://doi.org/10.1007/s11239-015-1230-6
Shah, Nirmish, Ian J. Welsby, Martha A. Fielder, Wayne K. Jacobsen, and Vance G. Nielsen. “Sickle cell disease is associated with iron mediated hypercoagulability.J Thromb Thrombolysis 40, no. 2 (August 2015): 182–85. https://doi.org/10.1007/s11239-015-1230-6.
Shah N, Welsby IJ, Fielder MA, Jacobsen WK, Nielsen VG. Sickle cell disease is associated with iron mediated hypercoagulability. J Thromb Thrombolysis. 2015 Aug;40(2):182–5.
Shah, Nirmish, et al. “Sickle cell disease is associated with iron mediated hypercoagulability.J Thromb Thrombolysis, vol. 40, no. 2, Aug. 2015, pp. 182–85. Pubmed, doi:10.1007/s11239-015-1230-6.
Shah N, Welsby IJ, Fielder MA, Jacobsen WK, Nielsen VG. Sickle cell disease is associated with iron mediated hypercoagulability. J Thromb Thrombolysis. 2015 Aug;40(2):182–185.
Journal cover image

Published In

J Thromb Thrombolysis

DOI

EISSN

1573-742X

Publication Date

August 2015

Volume

40

Issue

2

Start / End Page

182 / 185

Location

Netherlands

Related Subject Headings

  • Thrombophilia
  • Male
  • Iron Overload
  • Iron
  • Humans
  • Female
  • Child, Preschool
  • Child
  • Cardiovascular System & Hematology
  • Blood Coagulation