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A population-based study of prevalence and risk factors of chronic kidney disease in León, Nicaragua.

Publication ,  Journal Article
Lebov, JF; Valladares, E; Peña, R; Peña, EM; Sanoff, SL; Cisneros, EC; Colindres, RE; Morgan, DR; Hogan, SL
Published in: Can J Kidney Health Dis
2015

BACKGROUND: Recent studies have shown an excess of chronic kidney disease (CKD) among younger adult males in the Pacific coastal region of Nicaragua and suggest a non-conventional CKD etiology in this region. These studies have been conducted in small, non-representative populations. OBJECTIVES: We conducted a large population-based cross-sectional study to estimate CKD prevalence in León, Nicaragua, and to evaluate the association between previously investigated risk factors and CKD. METHODS: Estimated glomerular filtration rate, derived using the MDRD equation, was assessed to determine CKD status of 2275 León residents. Multivariable logistic regression was used to estimate adjusted prevalence odds ratios. León CKD prevalence was also standardized to the demographic distributions of the León Health and Demographic Surveillance System and the León 2005 Census. RESULTS: CKD prevalence was 9.1%; twice as high for males (13.8%) than females (5.8%). In addition to gender, older age, rural zone, lower education level, and self-reported high blood pressure, more years of agricultural work, lija (unregulated alcohol) consumption, and higher levels of daily water consumption were significantly associated with CKD. Notably, self-reported diabetes was associated with CKD in adjusted models for females but not males. CONCLUSIONS: Our findings are comparable to those found in regional studies and further support the hypothesis of a Mesoamerican Nephropathy.

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Published In

Can J Kidney Health Dis

DOI

ISSN

2054-3581

Publication Date

2015

Volume

2

Start / End Page

6

Location

England

Related Subject Headings

  • 3202 Clinical sciences
 

Citation

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Chicago
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MLA
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Lebov, J. F., Valladares, E., Peña, R., Peña, E. M., Sanoff, S. L., Cisneros, E. C., … Hogan, S. L. (2015). A population-based study of prevalence and risk factors of chronic kidney disease in León, Nicaragua. Can J Kidney Health Dis, 2, 6. https://doi.org/10.1186/s40697-015-0041-1
Lebov, Jill F., Eliette Valladares, Rodolfo Peña, Edgar M. Peña, Scott L. Sanoff, Efren Castellón Cisneros, Romulo E. Colindres, Douglas R. Morgan, and Susan L. Hogan. “A population-based study of prevalence and risk factors of chronic kidney disease in León, Nicaragua.Can J Kidney Health Dis 2 (2015): 6. https://doi.org/10.1186/s40697-015-0041-1.
Lebov JF, Valladares E, Peña R, Peña EM, Sanoff SL, Cisneros EC, et al. A population-based study of prevalence and risk factors of chronic kidney disease in León, Nicaragua. Can J Kidney Health Dis. 2015;2:6.
Lebov, Jill F., et al. “A population-based study of prevalence and risk factors of chronic kidney disease in León, Nicaragua.Can J Kidney Health Dis, vol. 2, 2015, p. 6. Pubmed, doi:10.1186/s40697-015-0041-1.
Lebov JF, Valladares E, Peña R, Peña EM, Sanoff SL, Cisneros EC, Colindres RE, Morgan DR, Hogan SL. A population-based study of prevalence and risk factors of chronic kidney disease in León, Nicaragua. Can J Kidney Health Dis. 2015;2:6.
Journal cover image

Published In

Can J Kidney Health Dis

DOI

ISSN

2054-3581

Publication Date

2015

Volume

2

Start / End Page

6

Location

England

Related Subject Headings

  • 3202 Clinical sciences