Genetics of pediatric epilepsy.
Publication
, Journal Article
Hani, AJ; Mikati, HM; Mikati, MA
Published in: Pediatr Clin North Am
June 2015
As the genetic etiologies of an expanding number of epilepsy syndromes are revealed, the complexity of the phenotype genotype correlation increases. As our review will show, multiple gene mutations cause different epilepsy syndromes, making identification of the specific mutation increasingly more important for prognostication and often more directed treatment. Examples of that include the need to avoid specific drugs in Dravet syndrome and the ongoing investigations of the potential use of new directed therapies such as retigabine in KCNQ2-related epilepsies, quinidine in KCNT1-related epilepsies, and memantine in GRIN2A-related epilepsies.
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Published In
Pediatr Clin North Am
DOI
EISSN
1557-8240
Publication Date
June 2015
Volume
62
Issue
3
Start / End Page
703 / 722
Location
United States
Related Subject Headings
- Phenotype
- Pediatrics
- Mutation
- Infant, Newborn
- Infant
- Humans
- Genotype
- Epilepsy
- Child, Preschool
- Child
Citation
APA
Chicago
ICMJE
MLA
NLM
Hani, A. J., Mikati, H. M., & Mikati, M. A. (2015). Genetics of pediatric epilepsy. Pediatr Clin North Am, 62(3), 703–722. https://doi.org/10.1016/j.pcl.2015.03.013
Hani, Abeer J., Husam M. Mikati, and Mohamad A. Mikati. “Genetics of pediatric epilepsy.” Pediatr Clin North Am 62, no. 3 (June 2015): 703–22. https://doi.org/10.1016/j.pcl.2015.03.013.
Hani AJ, Mikati HM, Mikati MA. Genetics of pediatric epilepsy. Pediatr Clin North Am. 2015 Jun;62(3):703–22.
Hani, Abeer J., et al. “Genetics of pediatric epilepsy.” Pediatr Clin North Am, vol. 62, no. 3, June 2015, pp. 703–22. Pubmed, doi:10.1016/j.pcl.2015.03.013.
Hani AJ, Mikati HM, Mikati MA. Genetics of pediatric epilepsy. Pediatr Clin North Am. 2015 Jun;62(3):703–722.
Published In
Pediatr Clin North Am
DOI
EISSN
1557-8240
Publication Date
June 2015
Volume
62
Issue
3
Start / End Page
703 / 722
Location
United States
Related Subject Headings
- Phenotype
- Pediatrics
- Mutation
- Infant, Newborn
- Infant
- Humans
- Genotype
- Epilepsy
- Child, Preschool
- Child