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IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral infection.

Publication ,  Journal Article
Yi, JS; Ingram, JT; Zajac, AJ
Published in: J Immunol
October 15, 2010

CD4 T cells are principal producers of IL-21 and are often required for optimal CD8 T cell responses. Therefore, we investigated the importance of IL-21 in determining the phenotypic attributes, functional quality, and maintenance of antiviral CD8 T cells following acute infection with the prototypic mouse pathogen lymphocytic choriomeningitis virus. Previous reports have documented an obligatory role for IL-21 in sustaining CD8 T cell responses during chronic infections. Here we show that the requirements for IL-21 are less stringent following acute infections; however, in the absence of IL-21, the capacity of CD8 T cells to attain the polyfunctional trait of IL-2 production is consistently reduced during both the effector and memory phases. This is further supported by in vitro studies showing that the addition of IL-21 promotes the differentiation of IL-2-producing CD8 T cells. Although the generation of memory CD8 T cells, which are capable of mounting protective recall responses, proceeds independently of IL-21, we demonstrate that IL-21 does function to support secondary responses, especially under competitive conditions. Collectively, these studies highlight the potential roles of IL-21 in determining the quality of CD8 T cell responses postinfection.

Duke Scholars

Published In

J Immunol

DOI

EISSN

1550-6606

Publication Date

October 15, 2010

Volume

185

Issue

8

Start / End Page

4835 / 4845

Location

United States

Related Subject Headings

  • Mice, Transgenic
  • Mice, Inbred C57BL
  • Mice
  • Lymphocytic Choriomeningitis
  • Lymphocyte Activation
  • Interleukins
  • Interleukin-2
  • Immunology
  • Immunologic Memory
  • Flow Cytometry
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yi, J. S., Ingram, J. T., & Zajac, A. J. (2010). IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral infection. J Immunol, 185(8), 4835–4845. https://doi.org/10.4049/jimmunol.1001032
Yi, John S., Jennifer T. Ingram, and Allan J. Zajac. “IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral infection.J Immunol 185, no. 8 (October 15, 2010): 4835–45. https://doi.org/10.4049/jimmunol.1001032.
Yi JS, Ingram JT, Zajac AJ. IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral infection. J Immunol. 2010 Oct 15;185(8):4835–45.
Yi, John S., et al. “IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral infection.J Immunol, vol. 185, no. 8, Oct. 2010, pp. 4835–45. Pubmed, doi:10.4049/jimmunol.1001032.
Yi JS, Ingram JT, Zajac AJ. IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral infection. J Immunol. 2010 Oct 15;185(8):4835–4845.

Published In

J Immunol

DOI

EISSN

1550-6606

Publication Date

October 15, 2010

Volume

185

Issue

8

Start / End Page

4835 / 4845

Location

United States

Related Subject Headings

  • Mice, Transgenic
  • Mice, Inbred C57BL
  • Mice
  • Lymphocytic Choriomeningitis
  • Lymphocyte Activation
  • Interleukins
  • Interleukin-2
  • Immunology
  • Immunologic Memory
  • Flow Cytometry