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Gene Expression Signatures and the Spectrum of Coronary Artery Disease.

Publication ,  Journal Article
Friede, KA; Ginsburg, GS; Voora, D
Published in: J Cardiovasc Transl Res
August 2015

Over the past 10-15 years, developments in gene expression profiling have opened new arenas for the discovery of important factors in the pathogenesis of numerous disease processes, including coronary artery disease. Messenger RNA and microRNA are differentially expressed in patients with coronary plaques, acute plaque rupture, and response to well-established treatments for acute coronary syndromes. In this review, we will explore recent developments in messenger RNA and microRNA technology at each stage of a patient's progression through the natural history of cardiovascular disease, including evaluation of risk factors, prediction and detection of coronary artery disease and acute coronary syndromes, and finally, response to treatments for coronary artery disease and its sequelae including congestive heart failure.

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Published In

J Cardiovasc Transl Res

DOI

EISSN

1937-5395

Publication Date

August 2015

Volume

8

Issue

6

Start / End Page

339 / 352

Location

United States

Related Subject Headings

  • Risk Factors
  • RNA, Messenger
  • MicroRNAs
  • Humans
  • Gene Expression Profiling
  • Disease Progression
  • Coronary Artery Disease
  • 3201 Cardiovascular medicine and haematology
 

Citation

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Friede, K. A., Ginsburg, G. S., & Voora, D. (2015). Gene Expression Signatures and the Spectrum of Coronary Artery Disease. J Cardiovasc Transl Res, 8(6), 339–352. https://doi.org/10.1007/s12265-015-9640-6
Friede, Kevin A., Geoffrey S. Ginsburg, and Deepak Voora. “Gene Expression Signatures and the Spectrum of Coronary Artery Disease.J Cardiovasc Transl Res 8, no. 6 (August 2015): 339–52. https://doi.org/10.1007/s12265-015-9640-6.
Friede KA, Ginsburg GS, Voora D. Gene Expression Signatures and the Spectrum of Coronary Artery Disease. J Cardiovasc Transl Res. 2015 Aug;8(6):339–52.
Friede, Kevin A., et al. “Gene Expression Signatures and the Spectrum of Coronary Artery Disease.J Cardiovasc Transl Res, vol. 8, no. 6, Aug. 2015, pp. 339–52. Pubmed, doi:10.1007/s12265-015-9640-6.
Friede KA, Ginsburg GS, Voora D. Gene Expression Signatures and the Spectrum of Coronary Artery Disease. J Cardiovasc Transl Res. 2015 Aug;8(6):339–352.
Journal cover image

Published In

J Cardiovasc Transl Res

DOI

EISSN

1937-5395

Publication Date

August 2015

Volume

8

Issue

6

Start / End Page

339 / 352

Location

United States

Related Subject Headings

  • Risk Factors
  • RNA, Messenger
  • MicroRNAs
  • Humans
  • Gene Expression Profiling
  • Disease Progression
  • Coronary Artery Disease
  • 3201 Cardiovascular medicine and haematology