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Transcriptomic analysis of Nodal- and BMP-associated genes during juvenile development of the sea urchin Heliocidaris erythrogramma.

Publication ,  Journal Article
Byrne, M; Koop, D; Cisternas, P; Strbenac, D; Yang, JYH; Wray, GA
Published in: Marine genomics
December 2015

Understanding the unusual radial body plan of echinoderms and its relationship to the bilateral plan of other deuterostomes remains a challenge. The molecular processes of embryonic and early larval development in sea urchins are well characterised, but those giving rise to the adult and its radial body remain poorly studied. We used the developmental transcriptome generated for Heliocidaris erythrogramma, a species that forms the juvenile soon after gastrulation, to investigate changes in gene expression underlying radial body development. As coelomogenesis is key to the development of pentamery and juvenile formation on the left side of the larva, we focussed on genes associated with the nodal and BMP2/4 network that pattern this asymmetry. We identified 46 genes associated with this Nodal and BMP2/4 signalling network, and determined their expression profiles from the gastrula, through to rudiment development, metamorphosis and the fully formed juvenile. Genes associated with Nodal signalling shared similar expression profiles, indicating that they may have a regulatory relationship in patterning morphogenesis of the juvenile sea urchin. Similarly, many genes associated with BMP2/4 signalling had similar expression profiles through juvenile development. Further examination of the roles of Nodal- and BMP2/4-associated genes is required to determine function and whether the gene expression profiles seen in H. erythrogramma are due to ongoing activity of gene networks established during early development, or to redeployment of regulatory cassettes to pattern the adult radial body plan.

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Published In

Marine genomics

DOI

EISSN

1876-7478

ISSN

1874-7787

Publication Date

December 2015

Volume

24 Pt 1

Start / End Page

41 / 45

Related Subject Headings

  • Transcriptome
  • Signal Transduction
  • Nodal Protein
  • Gene Expression Regulation, Developmental
  • Bone Morphogenetic Proteins
  • Anthocidaris
  • Animals
  • 31 Biological sciences
  • 06 Biological Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Byrne, M., Koop, D., Cisternas, P., Strbenac, D., Yang, J. Y. H., & Wray, G. A. (2015). Transcriptomic analysis of Nodal- and BMP-associated genes during juvenile development of the sea urchin Heliocidaris erythrogramma. Marine Genomics, 24 Pt 1, 41–45. https://doi.org/10.1016/j.margen.2015.05.019
Byrne, Maria, Demian Koop, Paula Cisternas, Dario Strbenac, Jean Yee Hwa Yang, and Gregory A. Wray. “Transcriptomic analysis of Nodal- and BMP-associated genes during juvenile development of the sea urchin Heliocidaris erythrogramma.Marine Genomics 24 Pt 1 (December 2015): 41–45. https://doi.org/10.1016/j.margen.2015.05.019.
Byrne M, Koop D, Cisternas P, Strbenac D, Yang JYH, Wray GA. Transcriptomic analysis of Nodal- and BMP-associated genes during juvenile development of the sea urchin Heliocidaris erythrogramma. Marine genomics. 2015 Dec;24 Pt 1:41–5.
Byrne, Maria, et al. “Transcriptomic analysis of Nodal- and BMP-associated genes during juvenile development of the sea urchin Heliocidaris erythrogramma.Marine Genomics, vol. 24 Pt 1, Dec. 2015, pp. 41–45. Epmc, doi:10.1016/j.margen.2015.05.019.
Byrne M, Koop D, Cisternas P, Strbenac D, Yang JYH, Wray GA. Transcriptomic analysis of Nodal- and BMP-associated genes during juvenile development of the sea urchin Heliocidaris erythrogramma. Marine genomics. 2015 Dec;24 Pt 1:41–45.
Journal cover image

Published In

Marine genomics

DOI

EISSN

1876-7478

ISSN

1874-7787

Publication Date

December 2015

Volume

24 Pt 1

Start / End Page

41 / 45

Related Subject Headings

  • Transcriptome
  • Signal Transduction
  • Nodal Protein
  • Gene Expression Regulation, Developmental
  • Bone Morphogenetic Proteins
  • Anthocidaris
  • Animals
  • 31 Biological sciences
  • 06 Biological Sciences