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WE-G-BRD-06: Volumetric Cine MRI (VC-MRI) Estimated Based On Prior Knowledge for On-Board Target Localization.

Publication ,  Conference
Harris, W; Yin, F; Cai, J; Zhang, Y; Ren, L
Published in: Med Phys
June 2015

PURPOSE: To develop a technique to generate on-board VC-MRI using patient prior 4D-MRI, motion modeling and on-board 2D-cine MRI for real-time 3D target verification of liver and lung radiotherapy. METHODS: The end-expiration phase images of a 4D-MRI acquired during patient simulation are used as patient prior images. Principal component analysis (PCA) is used to extract 3 major respiratory deformation patterns from the Deformation Field Maps (DFMs) generated between end-expiration phase and all other phases. On-board 2D-cine MRI images are acquired in the axial view. The on-board VC-MRI at any instant is considered as a deformation of the prior MRI at the end-expiration phase. The DFM is represented as a linear combination of the 3 major deformation patterns. The coefficients of the deformation patterns are solved by matching the corresponding 2D slice of the estimated VC-MRI with the acquired single 2D-cine MRI. The method was evaluated using both XCAT (a computerized patient model) simulation of lung cancer patients and MRI data from a real liver cancer patient. The 3D-MRI at every phase except end-expiration phase was used to simulate the ground-truth on-board VC-MRI at different instances, and the center-tumor slice was selected to simulate the on-board 2D-cine images. RESULTS: Image subtraction of ground truth with estimated on-board VC-MRI shows fewer differences than image subtraction of ground truth with prior image. Excellent agreement between profiles was achieved. The normalized cross correlation coefficients between the estimated and ground-truth in the axial, coronal and sagittal views for each time step were >= 0.982, 0.905, 0.961 for XCAT data and >= 0.998, 0.911, 0.9541 for patient data. For XCAT data, the maximum-Volume-Percent-Difference between ground-truth and estimated tumor volumes was 1.6% and the maximum-Center-of-Mass-Shift was 0.9 mm. CONCLUSION: Preliminary studies demonstrated the feasibility to estimate real-time VC-MRI for on-board target localization before or during radiotherapy treatments. National Institutes of Health Grant No. R01-CA184173; Varian Medical System.

Duke Scholars

Published In

Med Phys

DOI

ISSN

0094-2405

Publication Date

June 2015

Volume

42

Issue

6

Start / End Page

3689

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Harris, W., Yin, F., Cai, J., Zhang, Y., & Ren, L. (2015). WE-G-BRD-06: Volumetric Cine MRI (VC-MRI) Estimated Based On Prior Knowledge for On-Board Target Localization. In Med Phys (Vol. 42, p. 3689). United States. https://doi.org/10.1118/1.4926062
Harris, W., F. Yin, J. Cai, Y. Zhang, and L. Ren. “WE-G-BRD-06: Volumetric Cine MRI (VC-MRI) Estimated Based On Prior Knowledge for On-Board Target Localization.” In Med Phys, 42:3689, 2015. https://doi.org/10.1118/1.4926062.
Harris, W., et al. “WE-G-BRD-06: Volumetric Cine MRI (VC-MRI) Estimated Based On Prior Knowledge for On-Board Target Localization.Med Phys, vol. 42, no. 6, 2015, p. 3689. Pubmed, doi:10.1118/1.4926062.

Published In

Med Phys

DOI

ISSN

0094-2405

Publication Date

June 2015

Volume

42

Issue

6

Start / End Page

3689

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences