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Assessment of Treatment Response With Diffusion-Weighted MRI and Dynamic Contrast-Enhanced MRI in Patients With Early-Stage Breast Cancer Treated With Single-Dose Preoperative Radiotherapy: Initial Results.

Publication ,  Journal Article
Wang, C; Horton, JK; Yin, F-F; Chang, Z
Published in: Technol Cancer Res Treat
October 2016

Single-dose preoperative stereotactic body radiotherapy is a novel radiotherapy technique for the early-stage breast cancer, and the treatment response pattern of this technique needs to be investigated on a quantitative basis. In this work, dynamic contrast-enhanced magnetic resonance imaging and diffusion-weighted magnetic resonance imaging were used to study the treatment response pattern in a unique cohort of patients with early-stage breast cancer treated with preoperative radiation. Fifteen female qualified patients received single-dose preoperative radiotherapy with 1 of the 3 prescription doses: 15 Gy, 18 Gy, and 21 Gy. Magnetic resonance imaging scans including both diffusion-weighted magnetic resonance imaging and dynamic contrast-enhanced magnetic resonance imaging were acquired before radiotherapy for planning and after radiotherapy but before surgical resection. In diffusion-weighted magnetic resonance imaging, the regional averaged apparent diffusion coefficient was calculated. In dynamic contrast-enhanced magnetic resonance imaging, quantitative parameters K (trans) and v e were evaluated using the standard Tofts model based on the average contrast agent concentration within the region of interest, and the semiquantitative initial area under the concentration curve (iAUC6min) was also recorded. These parameters' relative changes after radiotherapy were calculated for gross tumor volume, clinical target volume, and planning target volume. The initial results showed that after radiotherapy, initial area under the concentration curve significantly increased in planning target volume (P < .006) and clinical target volume (P < .006), and v e significantly increased in planning target volume (P < .05) and clinical target volume (P < .05). Statistical studies suggested that linear correlations between treatment dose and the observed parameter changes exist in most examined tests, and among these tests, the change in gross tumor volume regional averaged apparent diffusion coefficient (P < .012) and between treatment dose and planning target volume K (trans) (P < .029) were found to be statistically significant. Although it is still preliminary, this pilot study may be useful to provide insights for future works.

Duke Scholars

Published In

Technol Cancer Res Treat

DOI

EISSN

1533-0338

Publication Date

October 2016

Volume

15

Issue

5

Start / End Page

651 / 660

Location

United States

Related Subject Headings

  • Tumor Burden
  • Treatment Outcome
  • Radiotherapy Dosage
  • Preoperative Care
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Middle Aged
  • Magnetic Resonance Imaging
  • Image Enhancement
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Wang, C., Horton, J. K., Yin, F.-F., & Chang, Z. (2016). Assessment of Treatment Response With Diffusion-Weighted MRI and Dynamic Contrast-Enhanced MRI in Patients With Early-Stage Breast Cancer Treated With Single-Dose Preoperative Radiotherapy: Initial Results. Technol Cancer Res Treat, 15(5), 651–660. https://doi.org/10.1177/1533034615593191
Wang, Chunhao, Janet K. Horton, Fang-Fang Yin, and Zheng Chang. “Assessment of Treatment Response With Diffusion-Weighted MRI and Dynamic Contrast-Enhanced MRI in Patients With Early-Stage Breast Cancer Treated With Single-Dose Preoperative Radiotherapy: Initial Results.Technol Cancer Res Treat 15, no. 5 (October 2016): 651–60. https://doi.org/10.1177/1533034615593191.
Journal cover image

Published In

Technol Cancer Res Treat

DOI

EISSN

1533-0338

Publication Date

October 2016

Volume

15

Issue

5

Start / End Page

651 / 660

Location

United States

Related Subject Headings

  • Tumor Burden
  • Treatment Outcome
  • Radiotherapy Dosage
  • Preoperative Care
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Middle Aged
  • Magnetic Resonance Imaging
  • Image Enhancement
  • Humans