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SU-E-T-317: Dosimetric Evaluation of Acuros XB Advanced Dose Calculation Algorithm in Head and Neck Patients.

Publication ,  Journal Article
Faught, A; Wu, Q
Published in: Med Phys
June 2015

PURPOSE: The Acuros XB photon dose calculation algorithm is a newly implemented calculation technique within the Eclipse treatment planning system using deterministic solutions to the linear Boltzmann transport equations. The goal of this study is to assess the clinical impact of dose differences arising from a retrospective comparison of calculations performed using the Analytical Anisotropic Algorithm (AAA) and Acuros XB on patients. METHODS: Ten head and neck patients receiving intensity modulated radiation therapy were selected as a pilot study. Initial evaluation was based on the percentage of the planning target volume (PTV) covered by the prescription dose, minimum dose within the PTV, and dose differences in critical structures. For patients receiving boost plans, dosimetric evaluations were performed on the plan sum of the primary and boost plans. RESULTS: Among the ten patients there were a total of 21 PTVs corresponding to primary and boost volumes. Using the same normalization within Eclipse, the average percentage of the PTVs receiving the prescription dose were 95.6% for AAA and Acuros XB. The average minimum doses within the PTVs, expressed as a percentage of the prescription to the volume, were 82.3% and 83.6% for AAA and Acuros XB respectively. Neither comparison showed differences with statistical significance when subjected to a paired t-test. Statistical significance was found in the average difference of the maximum dose for the mandible (242.5cGy, p=0.0005) and cord with a 5mm radial expansion (105.0cGy, p=0.0005) and in the median dose for the left parotid (25.0cGy, p=0.0423) and oral cavity (36.3cGy, p=0.002). CONCLUSION: The Acuros XB dose calculation algorithm did not exhibit significant differences in PTV coverage when compared to the AAA algorithm. Significant differences in critical structures are likely attributed to the structures proximity to high atomic number materials or air cavities, regions of known difficulty for the AAA algorithm.

Duke Scholars

Published In

Med Phys

DOI

ISSN

0094-2405

Publication Date

June 2015

Volume

42

Issue

6

Start / End Page

3406

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Faught, A., & Wu, Q. (2015). SU-E-T-317: Dosimetric Evaluation of Acuros XB Advanced Dose Calculation Algorithm in Head and Neck Patients. Med Phys, 42(6), 3406. https://doi.org/10.1118/1.4924678
Faught, A., and Q. Wu. “SU-E-T-317: Dosimetric Evaluation of Acuros XB Advanced Dose Calculation Algorithm in Head and Neck Patients.Med Phys 42, no. 6 (June 2015): 3406. https://doi.org/10.1118/1.4924678.
Faught, A., and Q. Wu. “SU-E-T-317: Dosimetric Evaluation of Acuros XB Advanced Dose Calculation Algorithm in Head and Neck Patients.Med Phys, vol. 42, no. 6, June 2015, p. 3406. Pubmed, doi:10.1118/1.4924678.

Published In

Med Phys

DOI

ISSN

0094-2405

Publication Date

June 2015

Volume

42

Issue

6

Start / End Page

3406

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences