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Genomic Classification of Cutaneous Melanoma.

Publication ,  Journal Article
Published in: Cell
June 18, 2015

We describe the landscape of genomic alterations in cutaneous melanomas through DNA, RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 patients. We establish a framework for genomic classification into one of four subtypes based on the pattern of the most prevalent significantly mutated genes: mutant BRAF, mutant RAS, mutant NF1, and Triple-WT (wild-type). Integrative analysis reveals enrichment of KIT mutations and focal amplifications and complex structural rearrangements as a feature of the Triple-WT subtype. We found no significant outcome correlation with genomic classification, but samples assigned a transcriptomic subclass enriched for immune gene expression associated with lymphocyte infiltrate on pathology review and high LCK protein expression, a T cell marker, were associated with improved patient survival. This clinicopathological and multi-dimensional analysis suggests that the prognosis of melanoma patients with regional metastases is influenced by tumor stroma immunobiology, offering insights to further personalize therapeutic decision-making.

Duke Scholars

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Published In

Cell

DOI

EISSN

1097-4172

Publication Date

June 18, 2015

Volume

161

Issue

7

Start / End Page

1681 / 1696

Location

United States

Related Subject Headings

  • United States
  • Skin Neoplasms
  • National Cancer Institute (U.S.)
  • Mutation
  • Melanoma
  • Humans
  • Developmental Biology
  • Databases, Genetic
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
 

Citation

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Genomic Classification of Cutaneous Melanoma. (2015). Cell, 161(7), 1681–1696. https://doi.org/10.1016/j.cell.2015.05.044
Genomic Classification of Cutaneous Melanoma.Cell 161, no. 7 (June 18, 2015): 1681–96. https://doi.org/10.1016/j.cell.2015.05.044.
Genomic Classification of Cutaneous Melanoma. Cell. 2015 Jun 18;161(7):1681–96.
Genomic Classification of Cutaneous Melanoma.Cell, vol. 161, no. 7, June 2015, pp. 1681–96. Pubmed, doi:10.1016/j.cell.2015.05.044.
Genomic Classification of Cutaneous Melanoma. Cell. 2015 Jun 18;161(7):1681–1696.
Journal cover image

Published In

Cell

DOI

EISSN

1097-4172

Publication Date

June 18, 2015

Volume

161

Issue

7

Start / End Page

1681 / 1696

Location

United States

Related Subject Headings

  • United States
  • Skin Neoplasms
  • National Cancer Institute (U.S.)
  • Mutation
  • Melanoma
  • Humans
  • Developmental Biology
  • Databases, Genetic
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences