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Revisiting mortimer's genome renewal hypothesis: Heterozygosity, homothallism, and the potential for adaptation in yeast

Publication ,  Journal Article
Magwene, PM
Published in: Advances in Experimental Medicine and Biology
January 1, 2014

In diploid organisms, the frequency and nature of sexual cycles have a major impact on genome-wide patterns of heterozygosity. Recent population genomic surveys in the budding yeast, Saccharomyces cerevisiae, have revealed surprising levels of genomic heterozygosity in what has been traditionally considered a highly inbred organism. I review evidence and hypotheses regarding the generation, maintenance, and evolutionary consequences of genomic heterozygosity in S. cerevisiae. I propose that high levels of heterozygosity in S. cerevisiae, arising from population admixture due to human domestication, coupled with selfing during rare sexual cycles, can facilitate rapid adaptation to novel environments. © 2014 Springer Science+Business Media Dordrecht.

Duke Scholars

Published In

Advances in Experimental Medicine and Biology

DOI

ISSN

0065-2598

Publication Date

January 1, 2014

Volume

781

Start / End Page

37 / 48

Related Subject Headings

  • General & Internal Medicine
  • 11 Medical and Health Sciences
 

Citation

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Magwene, P. M. (2014). Revisiting mortimer's genome renewal hypothesis: Heterozygosity, homothallism, and the potential for adaptation in yeast. Advances in Experimental Medicine and Biology, 781, 37–48. https://doi.org/10.1007/978-94-7-7347-9_3
Magwene, P. M. “Revisiting mortimer's genome renewal hypothesis: Heterozygosity, homothallism, and the potential for adaptation in yeast.” Advances in Experimental Medicine and Biology 781 (January 1, 2014): 37–48. https://doi.org/10.1007/978-94-7-7347-9_3.
Magwene PM. Revisiting mortimer's genome renewal hypothesis: Heterozygosity, homothallism, and the potential for adaptation in yeast. Advances in Experimental Medicine and Biology. 2014 Jan 1;781:37–48.
Magwene, P. M. “Revisiting mortimer's genome renewal hypothesis: Heterozygosity, homothallism, and the potential for adaptation in yeast.” Advances in Experimental Medicine and Biology, vol. 781, Jan. 2014, pp. 37–48. Scopus, doi:10.1007/978-94-7-7347-9_3.
Magwene PM. Revisiting mortimer's genome renewal hypothesis: Heterozygosity, homothallism, and the potential for adaptation in yeast. Advances in Experimental Medicine and Biology. 2014 Jan 1;781:37–48.

Published In

Advances in Experimental Medicine and Biology

DOI

ISSN

0065-2598

Publication Date

January 1, 2014

Volume

781

Start / End Page

37 / 48

Related Subject Headings

  • General & Internal Medicine
  • 11 Medical and Health Sciences