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Effect of aerobic training on the host systemic milieu in patients with solid tumours: An exploratory correlative study

Publication ,  Journal Article
Glass, OK; Inman, BA; Broadwater, G; Courneya, KS; Mackey, JR; Goruk, S; Nelson, ER; Jasper, J; Field, CJ; Bain, JR; Muehlbauer, M; Jones, LW ...
Published in: British Journal of Cancer
March 3, 2015

Background: Few studies have investigated the effects of exercise on modulation of host factors in cancer patients. We investigated the efficacy of chronic aerobic training on multiple host-related effector pathways in patients with solid tumours.Patients and Methods:Paired peripheral blood samples were obtained from 44 patients with solid tumours receiving cytotoxic therapy and synthetic erythropoietin (usual care; n=21) or usual care plus supervised aerobic training (n=23) for 12 weeks. Samples were characterised for changes in immune, cytokine and angiogenic factors, and metabolic intermediates. Aerobic training consisted of three supervised cycle ergometry sessions per week at 60% to 100% of peak oxygen consumption (VO 2peak), 30-45 min per session, for 12 weeks following a nonlinear prescription.Results:The between-group delta change in cardiopulmonary function was +4.1 ml kg-1 min-1, favouring aerobic training (P<0.05). Significant pre-post between-group differences for five cytokine and angiogenic factors (HGF, IL-4, macrophage inflammatory protein-1β (MIP-1β), vascular endothelial growth factor (VEGF), and TNF-) also favour the aerobic training group (P's<0.05). These reductions occurred in conjunction with nonsignificant group differences for T lymphocytes CD4 +, CD8 +, and CD8 +/CD45RA (P<0.10). For these factors, circulating concentrations generally increased from baseline to week 12 in the aerobic training group compared with decreases or no change in the usual care group. No significant changes in any metabolic intermediates were observed.Conclusions:Aerobic training alters host availability of select immune-inflammatory effectors in patients with solid tumours; larger confirmatory studies in more homogenous samples are warranted.

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Published In

British Journal of Cancer

DOI

EISSN

1532-1827

ISSN

0007-0920

Publication Date

March 3, 2015

Volume

112

Issue

5

Start / End Page

825 / 831

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 1117 Public Health and Health Services
  • 1112 Oncology and Carcinogenesis
 

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MLA
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Glass, O. K., Inman, B. A., Broadwater, G., Courneya, K. S., Mackey, J. R., Goruk, S., … Jones, L. W. (2015). Effect of aerobic training on the host systemic milieu in patients with solid tumours: An exploratory correlative study. British Journal of Cancer, 112(5), 825–831. https://doi.org/10.1038/bjc.2014.662
Glass, O. K., B. A. Inman, G. Broadwater, K. S. Courneya, J. R. Mackey, S. Goruk, E. R. Nelson, et al. “Effect of aerobic training on the host systemic milieu in patients with solid tumours: An exploratory correlative study.” British Journal of Cancer 112, no. 5 (March 3, 2015): 825–31. https://doi.org/10.1038/bjc.2014.662.
Glass OK, Inman BA, Broadwater G, Courneya KS, Mackey JR, Goruk S, et al. Effect of aerobic training on the host systemic milieu in patients with solid tumours: An exploratory correlative study. British Journal of Cancer. 2015 Mar 3;112(5):825–31.
Glass, O. K., et al. “Effect of aerobic training on the host systemic milieu in patients with solid tumours: An exploratory correlative study.” British Journal of Cancer, vol. 112, no. 5, Mar. 2015, pp. 825–31. Scopus, doi:10.1038/bjc.2014.662.
Glass OK, Inman BA, Broadwater G, Courneya KS, Mackey JR, Goruk S, Nelson ER, Jasper J, Field CJ, Bain JR, Muehlbauer M, Stevens RD, Hirschey MD, Jones LW. Effect of aerobic training on the host systemic milieu in patients with solid tumours: An exploratory correlative study. British Journal of Cancer. 2015 Mar 3;112(5):825–831.

Published In

British Journal of Cancer

DOI

EISSN

1532-1827

ISSN

0007-0920

Publication Date

March 3, 2015

Volume

112

Issue

5

Start / End Page

825 / 831

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 1117 Public Health and Health Services
  • 1112 Oncology and Carcinogenesis