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Multipotent stem cells in cardiac regenerative therapy.

Publication ,  Journal Article
Karra, R; Wu, SM
Published in: Regen Med
March 2008

The potential for stem cells to ameliorate or cure heart diseases has galvanized a cadre of cardiovascular translational and clinical scientists to take a 'first-in-man' approach using autologous stem cells from a variety of tissues. However, recent clinical trial data show that when these cells are given by intracoronary infusion or direct myocardial injection, limited improvement in heart function occurs with no evidence of cardiomyogenesis. These studies illustrate the great need to understand the logic of cell-lineage commitment and the principles of cardiac differentiation. Recent identification of stem/progenitor cells of embryological origin with intrinsic competence to differentiate into multiple lineages within the heart offers new possibilities for cardiac regeneration. When combined with developments in nuclear reprogramming and provided that tumor risks and other challenges of embryonic cell transplantation can be overcome, the prospect of achieving autologous, cardiomyogenic, stem cell-based therapy may be within reach.

Duke Scholars

Published In

Regen Med

DOI

EISSN

1746-076X

Publication Date

March 2008

Volume

3

Issue

2

Start / End Page

189 / 198

Location

England

Related Subject Headings

  • Regeneration
  • Multipotent Stem Cells
  • Humans
  • Heart
  • Granulocyte Colony-Stimulating Factor
  • Developmental Biology
  • Clinical Trials as Topic
  • Bone Marrow Cells
  • Animals
  • Adult
 

Citation

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MLA
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Karra, R., & Wu, S. M. (2008). Multipotent stem cells in cardiac regenerative therapy. Regen Med, 3(2), 189–198. https://doi.org/10.2217/17460751.3.2.189
Karra, Ravi, and Sean M. Wu. “Multipotent stem cells in cardiac regenerative therapy.Regen Med 3, no. 2 (March 2008): 189–98. https://doi.org/10.2217/17460751.3.2.189.
Karra R, Wu SM. Multipotent stem cells in cardiac regenerative therapy. Regen Med. 2008 Mar;3(2):189–98.
Karra, Ravi, and Sean M. Wu. “Multipotent stem cells in cardiac regenerative therapy.Regen Med, vol. 3, no. 2, Mar. 2008, pp. 189–98. Pubmed, doi:10.2217/17460751.3.2.189.
Karra R, Wu SM. Multipotent stem cells in cardiac regenerative therapy. Regen Med. 2008 Mar;3(2):189–198.
Journal cover image

Published In

Regen Med

DOI

EISSN

1746-076X

Publication Date

March 2008

Volume

3

Issue

2

Start / End Page

189 / 198

Location

England

Related Subject Headings

  • Regeneration
  • Multipotent Stem Cells
  • Humans
  • Heart
  • Granulocyte Colony-Stimulating Factor
  • Developmental Biology
  • Clinical Trials as Topic
  • Bone Marrow Cells
  • Animals
  • Adult