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Association between positive urine cultures and necrotizing enterocolitis in a large cohort of hospitalized infants.

Publication ,  Journal Article
Pineda, LC; Hornik, CP; Seed, PC; Cotten, CM; Laughon, MM; Bidegain, M; Clark, RH; Brian Smith, P
Published in: Early Hum Dev
October 2015

OBJECTIVE: We used a large research database to examine the association between urinary tract infections and necrotizing enterocolitis (NEC) in premature infants. METHODS: This retrospective data analysis included infants ≤32week gestational age and ≤1500g at birth who had urine cultures obtained at one of 322 neonatal intensive care units managed by the Pediatrix Medical Group from 1997 to 2012. The primary outcome was a diagnosis of NEC within 7days after urine culture. We used multivariable conditional logistic regression conditioned on postnatal age and controlling for gestational age, inotropic support on the day of culture, and mechanical ventilation on the day of culture to evaluate the association between urine culture result and NEC. RESULTS: We identified 25,816 infants who had 43,556 urine cultures obtained; 6586 (15.1%) of the cultures were positive. A diagnosis of NEC within 7days after culture was made in 334 (5.1%) of the 6586 positive cultures versus 1582 (4.3%) of the 36,970 negative cultures (p<0.01). On multivariable analysis, infants with any positive urine culture had increased risk of NEC (odds ratio [OR] 1.16, 95% confidence interval [CI] 1.02-1.31); the risk was higher when limited to Gram-negative organisms (OR 1.37, 95% CI 1.17-1.59). The risk of surgical NEC was increased in infants with any positive urine culture (OR 1.46, 95% CI 1.18-1.81) and was also higher when limited to Gram-negative organisms (OR 1.99, 95% CI 1.53-2.59). CONCLUSION: Positive urine cultures were associated with increased risk of NEC within 7days of culture.

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Published In

Early Hum Dev

DOI

EISSN

1872-6232

Publication Date

October 2015

Volume

91

Issue

10

Start / End Page

583 / 586

Location

Ireland

Related Subject Headings

  • Urinary Tract Infections
  • Risk Factors
  • Retrospective Studies
  • Pediatrics
  • Multivariate Analysis
  • Male
  • Logistic Models
  • Infant, Premature
  • Infant, Newborn
  • Infant
 

Citation

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Pineda, L. C., Hornik, C. P., Seed, P. C., Cotten, C. M., Laughon, M. M., Bidegain, M., … Brian Smith, P. (2015). Association between positive urine cultures and necrotizing enterocolitis in a large cohort of hospitalized infants. Early Hum Dev, 91(10), 583–586. https://doi.org/10.1016/j.earlhumdev.2015.07.003
Pineda, Leslie C., Christoph P. Hornik, Patrick C. Seed, C Michael Cotten, Matthew M. Laughon, Margarita Bidegain, Reese H. Clark, and P. Brian Smith. “Association between positive urine cultures and necrotizing enterocolitis in a large cohort of hospitalized infants.Early Hum Dev 91, no. 10 (October 2015): 583–86. https://doi.org/10.1016/j.earlhumdev.2015.07.003.
Pineda LC, Hornik CP, Seed PC, Cotten CM, Laughon MM, Bidegain M, et al. Association between positive urine cultures and necrotizing enterocolitis in a large cohort of hospitalized infants. Early Hum Dev. 2015 Oct;91(10):583–6.
Pineda, Leslie C., et al. “Association between positive urine cultures and necrotizing enterocolitis in a large cohort of hospitalized infants.Early Hum Dev, vol. 91, no. 10, Oct. 2015, pp. 583–86. Pubmed, doi:10.1016/j.earlhumdev.2015.07.003.
Pineda LC, Hornik CP, Seed PC, Cotten CM, Laughon MM, Bidegain M, Clark RH, Brian Smith P. Association between positive urine cultures and necrotizing enterocolitis in a large cohort of hospitalized infants. Early Hum Dev. 2015 Oct;91(10):583–586.
Journal cover image

Published In

Early Hum Dev

DOI

EISSN

1872-6232

Publication Date

October 2015

Volume

91

Issue

10

Start / End Page

583 / 586

Location

Ireland

Related Subject Headings

  • Urinary Tract Infections
  • Risk Factors
  • Retrospective Studies
  • Pediatrics
  • Multivariate Analysis
  • Male
  • Logistic Models
  • Infant, Premature
  • Infant, Newborn
  • Infant