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Comparison of right and left ventricular function and size in Duchenne muscular dystrophy.

Publication ,  Journal Article
Mehmood, M; Hor, KN; Al-Khalidi, HR; Benson, DW; Jefferies, JL; Taylor, MD; Egnaczyk, GF; Raman, SV; Basu, SK; Cripe, LH; Germann, J; Mazur, W
Published in: Eur J Radiol
October 2015

INTRODUCTION: Right ventricular (RV) size and function in Duchenne muscular dystrophy (DMD) have not been well described. Using cardiac magnetic resonance (CMR) imaging we describe the relationship of RV and left ventricular (LV) size and function in a large DMD cohort. METHODS: Latest CMR scans of 272 patients consecutively seen at a single tertiary referral center (2011-2014) with skeletal muscle biopsy confirmed DMD were included. 1.5 and 3 Tesla CMR scanners were used. Biventricular ejection fraction (EF), end-diastolic volume index (EDVI), mass and mass index were compared across categories of LVEF. RESULTS: Mean age was 13.5 ± 4.9 years. 71% had normal (≥ 55%) LVEF while mild (EF 45-54%), moderate (EF 30-44%), and severe LV dysfunction (EF <30%) was present in 20%, 6% and 3% respectively. The correlation between RVEF and LVEF was weak. Even in patients with severe LV dysfunction, RVEF (49.7% ± 12.9%) was relatively preserved. There were no significant differences in RVEDVI and RV mass index across categories of LV function. CONCLUSION: In a large DMD cohort, RVEF was relatively preserved and RV size was preserved across categories of LV dysfunction.

Duke Scholars

Published In

Eur J Radiol

DOI

EISSN

1872-7727

Publication Date

October 2015

Volume

84

Issue

10

Start / End Page

1938 / 1942

Location

Ireland

Related Subject Headings

  • Young Adult
  • Ventricular Function, Right
  • Ventricular Function, Left
  • Ventricular Dysfunction, Left
  • Stroke Volume
  • Organ Size
  • Nuclear Medicine & Medical Imaging
  • Muscular Dystrophy, Duchenne
  • Male
  • Magnetic Resonance Imaging
 

Citation

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Mehmood, M., Hor, K. N., Al-Khalidi, H. R., Benson, D. W., Jefferies, J. L., Taylor, M. D., … Mazur, W. (2015). Comparison of right and left ventricular function and size in Duchenne muscular dystrophy. Eur J Radiol, 84(10), 1938–1942. https://doi.org/10.1016/j.ejrad.2015.07.007
Mehmood, Muddassir, Kan N. Hor, Hussein R. Al-Khalidi, D Woodrow Benson, John L. Jefferies, Michael D. Taylor, Gregory F. Egnaczyk, et al. “Comparison of right and left ventricular function and size in Duchenne muscular dystrophy.Eur J Radiol 84, no. 10 (October 2015): 1938–42. https://doi.org/10.1016/j.ejrad.2015.07.007.
Mehmood M, Hor KN, Al-Khalidi HR, Benson DW, Jefferies JL, Taylor MD, et al. Comparison of right and left ventricular function and size in Duchenne muscular dystrophy. Eur J Radiol. 2015 Oct;84(10):1938–42.
Mehmood, Muddassir, et al. “Comparison of right and left ventricular function and size in Duchenne muscular dystrophy.Eur J Radiol, vol. 84, no. 10, Oct. 2015, pp. 1938–42. Pubmed, doi:10.1016/j.ejrad.2015.07.007.
Mehmood M, Hor KN, Al-Khalidi HR, Benson DW, Jefferies JL, Taylor MD, Egnaczyk GF, Raman SV, Basu SK, Cripe LH, Germann J, Mazur W. Comparison of right and left ventricular function and size in Duchenne muscular dystrophy. Eur J Radiol. 2015 Oct;84(10):1938–1942.
Journal cover image

Published In

Eur J Radiol

DOI

EISSN

1872-7727

Publication Date

October 2015

Volume

84

Issue

10

Start / End Page

1938 / 1942

Location

Ireland

Related Subject Headings

  • Young Adult
  • Ventricular Function, Right
  • Ventricular Function, Left
  • Ventricular Dysfunction, Left
  • Stroke Volume
  • Organ Size
  • Nuclear Medicine & Medical Imaging
  • Muscular Dystrophy, Duchenne
  • Male
  • Magnetic Resonance Imaging